Indications | Pregnancy During Male Treatment, n | Dose, mg/wk | Treatment Maintained Until End of Pregnancy, n | Other Treatments, n | Outcomes* |
---|---|---|---|---|---|
Rheumatoid arthritis | 10 | 7.5–20 | 5 | Prednisone (1), hydroxychloroquine (1), etanercept (1) | 9 normal infants |
Psoriasis | 9 | 7.5–30 | 7 | Acitretin (1) | 7 normal infants, 1 SA |
Ankylosing spondylitis | 7 | 7.5–15 | 4 | Infliximab (1) | 6 normal infants |
Leukemia | 6 | 10–30 | 4 | Mercaptopurine (4), tretinoin (1), vincristine (1) | 4 normal infants, 2 SA |
Crohn’s disease | 2 | 25 | 4 | 2 normal infants | |
Adrenal tumor | 2 | 15 | 2 | 2 normal infants | |
Multiple sclerosis | 2 | 12, 5–20 | 2 | 2 normal infants | |
Lymphomatoid papulosis | 2 | 10–15 | 2 | 2 normal infants | |
Still’s disease | 1 | 20 | Azathioprine (1) | 1 normal infant | |
Sarcoidosis | 1 | 7.5 | 1 | Prednisone (1), lamotrigine (1) | 1 normal infant |
Total | 42 | 7.5–30 | 31/42 | 36 normal infants (92.3%) 3 SA (7.7%) |
↵* 3 voluntary abortions excluded from outcome calculations. SA: spontaneous abortion.