Table 3.

Studies describing clinical and pathological features of patients with isolated small-vessel (SV) inflammation on temporal artery biopsy (TAB).

CharacteristicCurrent ReportEsteban5Chatelain6Corcoran4
No. (total)4158490157
Study populationGCASVV–STA + comparator GCAGCA and PMRSV vasculitis on TAB
SV inflammation, n13283581
SV considered GCA, n13121727
Clinical features*
  Age, mean yrs75717571
  Headache, %54503440
  Jaw claudication, %150236
  PMR, %77678617
  TA abnormal, %3981710
  Fever, %23331716
  Weight loss, %3125113
  Visual symptoms, %38332046
  ESR, mean mm/h87 (100% > 50)96% > 507264% > 50
  Main TA infiltrate
  Small-vessel mononuclear infiltrate++++
  Polymorphonuclear cells+**
  Fibrinoid necrosis
  Lymphocyte phenotypeSmall vessel
T:B cell ratio = 1.33
  • * Data represent isolated small-vessel involvement in giant cell arteritis (GCA) (this report and Esteban, et al5); small-vessel involvement in GCA and/or polymyalgia rheumatica (PMR) (Chatelain, et al6); and small-vessel involvement in a 10-year sample of TAB, multiple diagnoses (Corcoran, et al4).

  • ** Utilized immunohistochemistry to detect polymorphonuclear cells.

  • Fibrinoid necrosis seen in small vessels in patients with small-vessel vasculitis but not GCA. SVV-STA: small-vessel vasculitis with spared temporal artery; ND: not done.