Significantly associated haplotypes for the 6 SNP. All haplotypes with a frequency < 0.03 were ignored in analysis. Loci chosen for analysis: rs26653, rs27434, rs27640, rs27529, rs26510, and rs27582.
| Haplotype | Case, % | Control, % | Chi-square | Fisher’s p | OR (95% CI) | PAR, % |
|---|---|---|---|---|---|---|
| GGTGT | 2.9 | 13.5 | 26.280 | 3.07e-007* | 0.183 (0.090, 0.374) | −4.3 |
| GATGT | 42.7 | 31.4 | 9.475 | 0.0021* | 1.684 (1.207, 2.349) | 4.3 |
| GACGT | 3.6 | 0.0 | 12.516 | 0.0004* | — | 1.2 |
| GGCAC | 5.1 | 7.6 | 2.064 | 0.1508 | 0.631 (0.335, 1.188) | — |
| CGTAC | 3.7 | 1.8 | 2.121 | 0.1453 | 2.037 (0.768, 5.407) | |
| CGCAC | 26.7 | 29.0 | 0.675 | 0.4113 | 0.864 (0.610, 1.224) |
↵* Significant after Bonferroni correction (p < 0.00833). SNP: single-nucleotide polymorphism; PAR: population-attributable risk.