Genes showing upregulated expression in peripheral blood from patients with secondary SS relative to controls (top 30).
| No. | Gene Name | Gene Bank No. | Mean Expression Level |
|---|---|---|---|
| 1* | ISG-56K (IFN-inducible 56k protein) | X03557 | 2.56 |
| 2* | MxA (interferon-induced cellular resistance mediator protein) | M30817 | 2.31 |
| 3* | Interferon-α-inducible protein 27 (IFI27; ISG12) | X67325 | 2.30 |
| 4* | IFN-α/ß/γ-inducible IFI-56K (IFI-56K) | M24594 | 2.25 |
| 5* | RIG-G, IFN-induced protein with tetratricopeptide repeats 4 (IFIT4) | U52513 | 2.15 |
| 6 | 2, 5-oligo-adenylate synthetase (2, 5-AS) 40/46 kDa (OAS1) | D00068 | 2.08 |
| 7* | IFN-α/ß-inducible p44 (p44) (IFI44) | NM_006417 | 2.07 |
| 8 | Ribosomal protein L41 | AF02844 | 2.04 |
| 9 | HLA-class II, DQ alpha 1 (HLA-DQA1) | M34996 | 1.96 |
| 10 | fte-1 (v-fos transformation effector protein), ribosomal protein S3a | M84711 | 1.95 |
| 11 | 2-5A synthetase (71 kDa) | M87434 | 1.83 |
| 12 | Ribosomal protein L7 (RPL7) | X57959 | 1.72 |
| 13 | 2-5A synthetase (1.8 kb RNA) | X02875 | 1.70 |
| 14 | Heat shock protein 90 alpha (HSPCA) | X15183 | 1.70 |
| 15* | IFN-inducible double-strand RNA-activated protein kinase (p68 kinase) (PKR) | M35663 | 1.69 |
| 16 | Ribosomal protein L36a (RPL36AL) | M15661 | 1.66 |
| 17 | Ribosomal protein S27 (RPS27) | U57847 | 1.66 |
| 18* | IFN-induced 17/15 kDa protein (G1P2) | M13755 | 1.60 |
| 19 | CX3C chemokine receptor-1 (CX3CR1) | BC028078 | 1.57 |
| 20 | NADH: ubiquinone oxidoreductase MLRQ subunit | U94586 | 1.55 |
| 21* | IFI-6-16, IFN-α-inducible (G1P3) | BC011601 | 1.52 |
| 22 | Ribosomal protein L11 (RPL11) | X79234 | 1.47 |
| 23 | Immunoglobulin heavy constant gamma 3 | J00230 | 1.46 |
| 24 | CD81 (antiproliferative antibody 1) | M33680 | 1.46 |
| 25 | Pros-27 (prosomal RNA-binding protein p27) | X59417 | 1.45 |
| 26 | Thymosin ß-10 (TMSB10) | M20259 | 1.45 |
| 27 | Granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) | BC015739 | 1.44 |
| 28 | Elongation factor 1-α (EEF1A1) | X16869 | 1.44 |
| 29 | Neuroleukin (NLK); glucose phosphate isomerase (GPI) | K03515 | 1.42 |
| 30* | STAT1α, IFN-α stimulated gene, transcription factor ISGF-3 (91 or 84 kD) | M97935 | 1.41 |
↵* Genes regulated by type I IFN.