Genes showing upregulated expression in peripheral blood from patients with primary SS relative to healthy controls (top 30). The average fold change is shown based on normalized microarray fluorescence data of SS patients compared to controls.
| No. | Gene Name | Gene Bank No. | Mean Expression Level |
|---|---|---|---|
| 1* | Interferon-α-inducible protein 27 (IFI27; ISG12) | X67325 | 56.0 |
| 2 | 2-5A synthetase (1.8 kb RNA) | X02875 | 3.82 |
| 3 | 2-5A synthetase (71 kDa) | M87434 | 3.52 |
| 4* | IFN-induced 17/15 kDa protein (G1P2) | M13755 | 3.44 |
| 5* | IFN-α/ß-inducible p44 (p44) (IFI44) | NM_006417 | 3.42 |
| 6* | MxA (interferon-induced cellular resistance mediator protein) | M30817 | 3.28 |
| 7 | 2, 5-oligo-adenylate synthetase (2, 5-AS) 40/46 kDa (OAS1) | D00068 | 2.87 |
| 8* | ISG-56K (IFN-inducible 56 k protein) | X03557 | 2.81 |
| 9 | Immunoglobulin heavy constant gamma 3 | J00230 | 2.76 |
| 10* | RIG-G, interferon-induced protein with tetratricopeptide repeats 4 (IFIT4) | U52513 | 2.72 |
| 11* | IFN-α/ß/γ-inducible IFI-56K (IFI-56K) | M24594 | 2.40 |
| 12 | Granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) (GZMB) | NM_004131 | 2.38 |
| 13 | Rearranged immunoglobulin mRNA for mu heavy chain enhancer and constant region | X58529 | 2.21 |
| 14* | IFI-6-16, IFN-α-inducible (G1P3) | BC011601 | 2.11 |
| 15 | Thymosin ß-10 (TMSB10) | M20259 | 2.11 |
| 16* | Interferon-inducible double-strand RNA-activated protein kinase (p68 kinase) (PKR) | M35663 | 2.11 |
| 17 | CD81 (antiproliferative antibody 1); 26 kDa cell surface protein TAPA-1 | M33680 | 2.10 |
| 18 | Ig-γ chain; Ig rearranged gamma chain, V-J-C region | M63438 | 1.99 |
| 19 | CX3C chemokine receptor-1 (CX3CR1) | BC028078 | 1.88 |
| 20* | Interferon regulatory factor 7 (IRF7) | U73036 | 1.81 |
| 21 | Mac-2 binding protein (macrophage scavenger receptor family) | L13210 | 1.78 |
| 22* | Interferon-inducible transmembrane protein 9-27 | J04164 | 1.77 |
| 23 | Immunoglobulin kappa (light chain) variable 1D8 | Y14736 | 1.77 |
| 24 | Perforin 1 (pore forming protein) (PRF1) | M28393 | 1.76 |
| 25 | BST-2 (bone marrow stromal antigen 2, synovial cell cDNA) | D28137 | 1.75 |
| 26 | TRIP14 (tyroid receptor interactor), eoxn 3 | L40387 | 1.67 |
| 27 | TCR ß chain; T-cell receptor beta chain | X00437 | 1.67 |
| 28* | STAT1α, IFN-α stimulated gene, transcription factor ISGF-3 (91 or 84 kD) | M97935 | 1.65 |
| 29 | CD2 (p50) | M16445 | 1.62 |
| 30 | bc12 homologous antagonist/killer 1 (BAK1) | U23765 | 1.61 |
↵* Genes regulated by type I IFN.