Table 2.

Distribution of FCRL3 SNP–169T/C genotype and allele frequencies in SLE patients with leukopenia and serositis (pleural effusion and pericardial effusion).

Characteristic (n)	Genotype			Minor Allele Frequency	p for Trend	Chi-square	Genotype Analysis (CC vs CT + TT) OR (95% CI)	p	Chi-square	Allele Analysis (C vs T) OR (95% CI)	p
Characteristic (n)	CC	CT	TT	Minor Allele Frequency	p for Trend	Chi-square	Genotype Analysis (CC vs CT + TT) OR (95% CI)	p	Chi-square	Allele Analysis (C vs T) OR (95% CI)	p
SLE (573)	85	293	195	0.416	0.543	1.291	0.841 (0.625–1.131)	0.256	0.360	0.953 (0.817–1.114)	0.549
Controls (758)	130	370	258	0.404
Leukopenia-positive (353)	38	187	128	0.373	0.049	7.644	0.583 (0.396–0.857)	6.1 × 10⁻³	3.709	0.835 (0.695–1.003)	0.054
Controls (758)	130	370	258	0.404
Leukopenia-positive (353)	38	187	128	0.373	0.005^*	11.654	0.444 (0.279–0.708)	6 × 10⁻⁴	7.552	0.712 (0.559–0.907)	0.006
Leukopenia-negative (220)	47	106	67	0.455
Serositis-positive (142)	26	77	39	0.454	0.044^*	1.794	1.413 (0.852–2.345)	0.181	3.942	1.316 (1.004–1.725)	0.047
Serositis-negative (431)	59	216	156	0.388
Female SLE (529)	81	267	181	0.406	0.590	0.628	0.880 (0.642–1.206)	0.428	0.283	0.956 (0.809–1.129)	0.595
Female controls (628)	107	309	212	0.416
Female leukopenia-positive (322)	37	168	117	0.454	0.013^*	9.021	0.481 (0.298–0.775)	2.7 × 10⁻³	6.010	0.731 (0.569–0.939)	0.014
Female leukopenia-negative (207)	44	99	64	0.388
Female serositis-positive (129)	26	68	35	0.465	0.025^*	3.053	1.584 (0.946–2.653)	0.081	5.014	1.382 (1.041–1.834)	0.025
Female serositis-negative (400)	55	199	146	0.386

↵* 100,000 permutations.