Table 4.

Comparison of isotypes of anti-ß2 glycoprotein I (anti-ß2-GPI) with serologic tests in systemic lupus erythematosus.

FactorIgG Anti-ß2-GPI Present*, %IgG Anti-ß2-GPI Absent, %pOR (95% CI)
Coombs positivity36.814.50.00103.37 (1.68–6.75)
Lupus anticoagulant (by RVVT)86.126.2< 0.000117.4 (7.22–41.8)
Anticardiolipin97.659.2< 0.000128.2 (3.85–206)
Anti-dsDNA74.456.40.02542.25 (1.12–4.53)
Anti-Sm14.318.50.68090.73 (0.30–1.77)
False-positive test for syphilis51.313.2< 0.00016.92 (3.55–13.5)
Low CH5028.212.50.01222.75 (1.32–5.73)
Low C369.851.20.01872.20 (1.13–4.28)
Low C467.445.60.00692.48 (1.29–4.76)
Anti-Ro/SSa21.430.00.29730.64 (0.30–1.35)
ESR88.477.00.09132.27 (0.88–5.86)
IgM Anti-ß2-GPI PresentIgM Anti-ß2-GPI Absent
Coombs positivity25.014.20.00702.01 (1.24–3.28)
Lupus anticoagulant (by RVVT)52.425.2< 0.00013.28 (2.21–4.86)
Anticardiolipin84.057.0< 0.00013.96 (2.40–6.55)
Anti-dsDNA63.256.30.16771.33 (0.90–1.98)
Anti-Sm13.119.30.12540.63 (0.36–1.11)
False positive test for syphilis35.111.5< 0.00014.15 (2.62–6.57)
Low CH5017.712.50.14051.50 (0.88–2.55)
Low C358.451.10.14341.35 (0.91–1.96)
Low C452.845.60.14381.33 (0.91–1.96)
Anti-Ro/SSA21.831.00.04140.62 (0.39–0.98)
ESR78.477.50.90691.06 (0.66–1.68)
IgA Anti-ß2-GPI PresentIgA Anti-ß2-GPI Absent
Coombs positivity20.714.70.09321.51 (0.94–2.42)
Lupus anticoagulant (by RVVT)48.724.6< 0.00012.91 (2.03–4.18)
Anticardiolipin77.557.1< 0.00012.58 (1.73–3.87)
Anti-dsDNA76.952.4< 0.00013.02 (2.03–4.50)
Anti-Sm24.216.80.03731.58 (1.04–2.41)
False positive test for syphilis28.611.8< 0.00012.98 (1.92–4.62)
Low CH5022.510.90.00042.37 (1.49–3.77)
Low C370.647.5< 0.00012.66 (1.83–3.86)
Low C462.542.7< 0.00012.23 (1.56–3.19)
Anti-Ro/SSA32.928.70.32891.22 (0.84–1.77)
ESR88.774.80.00012.64 (1.56–4.45)
  • * Positive value ≥ 20 phospholipid units. RVVT: Russell viper venom time; ESR: erythrocyte sedimentation rate.