The WEST study. Changes in Oswestry Disability Scores from baseline to followup, on all items, A only, and P only items, for the treatment (ESI) and the placebo (PL) groups. P values were based on ANOVA adjusting for baseline scores.
| Change in Score Between Baseline and Weeks 3, 6, 12, 26, and 52 (SD) | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Baseline Score (SD) | 3 | 6 | 12 | 26 | 52 | |||||||
| ESI | PL | ESI | PL | ESI | PL | ESI | PL | ESI | PL | ESI | PL | |
| All items, score (SD) | 44 (15) | 45 (18) | 10 (15) | 7 (16) | 13 (17) | 10 (18) | 12 (19) | 12 (21) | 12 (20) | 11 (22) | 21 (22) | 20 (24) |
| Mean difference (95% CI) | 3.7 (−0.25, 7.6) | 2.5 (−2.1, 7.2) | 0.25 (−4.9, 5.4) | 0.74 (−4.6, 6.1) | 1.57 (−4.5, 7.6) | |||||||
| Effect size | 0.23 | 0.14 | 0.01 | 0.04 | 0.07 | |||||||
| p | 0.052 | 0.60 | 0.97 | 0.58 | 0.33 | |||||||
| A only | 41 (15) | 42 (18) | 7.9 (13) | 5.2 (16) | 10 (16) | 8 (18) | 9 (17) | 9 (20) | 9 (18) | 9 (21) | 17 (21) | 17 (23) |
| Mean difference (95% CI) | 2.6 (−1.2, 6.5) | 2.0 (−2.4, 6.5) | −0.17 (−4.9, 4.6) | 0.48 (−4.6, 5.6) | 0.43 (−5.2, 6.1) | |||||||
| Effect size | 0.18 | 0.12 | −0.01 | 0.02 | 0.02 | |||||||
| p | 0.05 | 0.32 | 0.81 | 0.60 | 0.37 | |||||||
| P only items | 47 (21) | 49 (26) | 13 (20) | 8 (21) | 16 (23) | 12 (23) | 14 (25) | 15 (27) | 14 (25) | 13 (26) | 25 (27) | 23 (32) |
| Mean difference (95% CI) | 4.4 (−0.95, 9.8) | 3.7 (−2.4, 9.8) | −0.21 (−7.0, 6.6) | 0.9 (−5.9, 7.6) | 1.5 (−6.1, 9.2) | |||||||
| Effect size | 0.21 | 0.16 | −0.01 | 0.03 | 0.05 | |||||||
| p | 0.01 | 0.05 | 0.38 | 0.28 | 0.12 | |||||||
WEST: Wessex Epidural Steroids Trial; A: activity limitation; P: participation restriction; ESI: epidural steroids injection.