Characteristic | ADEPT Adalimumab Patients, N = 151 | ACCLAIM All Patients, N = 127 | ACCLAIM Anti-TNF-naive Patients, N = 90 | ACCLAIM Anti-TNF-Experienced Patients, N = 37 | p* |
---|---|---|---|---|---|
Age, yrs | 48.6 ± 12.5 | 48.8 ± 10.7 | 48.3 ± 11.1 | 50.1 ± 9.7 | 0.402 |
Male, n (%) | 85 (56.3) | 69 (54.3) | 46 (51.1) | 23 (62.2) | 0.328 |
White, n (%) | 147 (97.4) | 114 (89.8) | 78 (86.7) | 36 (97.3) | 0.106 |
Body weight, kg | 86.0 ± 20.6 | 90.5 ± 21.7 | 87.5 ± 19.8 | 97.6 ± 24.4 | 0.016 |
Duration of psoriatic arthritis, yrs | 9.8 ± 8.3 | 11.1 ± 8.8 | 10.6 ± 8.6 | 12.1 ± 9.3 | 0.381 |
Duration of psoriasis, yrs | 17.2 ± 12.0 | 21.1 ± 11.8 | 19.5 ± 11.4 | 24.8 ± 11.9 | 0.021 |
Arthritis subtype, n (%) | |||||
Symmetric polyarthritis | 97 (64.2) | 89 (70.1) | 63 (70.0) | 26 (70.3) | 0.999 |
Asymmetric oligoarthritis | 37 (24.5) | 22 (17.3) | 20 (22.2) | 2 (5.4) | 0.036 |
Distal interphalangeal arthropathy | 15 (9.9) | 11 (8.7) | 4 (4.4) | 7 (18.9) | 0.013 |
Spondylitis | 1 (0.7) | 3 (2.4) | 2 (2.2) | 1 (2.7) | 0.999 |
Arthritis mutilans | 1 (0.7) | 0 | 0 | 0 | — |
Tender joint count (0–78) | 23.9 ± 17.3 | 25.4 ± 16.4 | 23.5 ± 16.7 | 30.1 ± 15.0 | 0.037 |
Swollen joint count (0–76) | 14.3 ± 12.2 | 16.5 ± 10.9 | 15.7 ± 10.8 | 18.3 ± 11.3 | 0.232 |
Physician’s global assessment of disease activity (0–100-mm VAS) | 53.8 ± 15.7 | 60.9 ± 20.8 | 57.7 ± 21.7 | 68.7 ± 16.1 | 0.002 |
Patient’s global assessment of disease activity (0–100-mm VAS) | 47.1 ± 23.2 | 58.2 ± 24.4 | 53.7 ± 24.5 | 69.3 ± 20.7 | 0.001 |
Patient’s global assessment of pain (0–100-mm VAS) | 51.1 ± 21.4 | 55.9 ± 24.5 | 51.0 ± 25.0 | 67.7 ± 18.5 | < 0.001 |
Psoriasis Area and Severity Index score (0–72) | 7.4 ± 6.0 | 11.7 ± 8.0 | 10.0 ± 6.5 | 14.3 ± 9.5 | 0.047 |
C-reactive protein, mg/dl | 1.4 ± 2.1 | 1.3 ± 1.8 | 1.3 ± 2.0 | 1.5 ± 1.9 | 0.486 |
Health Assessment Questionnaire Disability Index | 1.0 ± 0.6 | 1.1 ± 0.7 | 1.0 ± 0.7 | 1.3 ± 0.7 | 0.062 |
↵* P values comparing anti-TNF-naive and anti-TNF-experienced patients based on chi-square test for categorical variables and independent samples t-test for continuous variables. VAS: visual analog scale.