Results of association analysis for response to MTX of the 5 SNP tested in 119 subjects, using logistic regression analysis adjusted for concomitant medications.
| 50% Reduction in Actively Inflamed Joint Count | |||||
|---|---|---|---|---|---|
| Counts | Logistic Regression Output | ||||
| Allele | Yes | No | p (Fisher) | OR (95% CI) | p |
| MTHFR 677T | 28/49 | 32/54 | 0.84 | 0.95 (0.41, 2.15) | 0.89 |
| MTHFR 1298C | 27/49 | 27/54 | 0.69 | 1.25 (0.55, 2.84) | 0.59 |
| DHFR −473T | 13/46 | 17/49 | 0.52 | 0.65 (0.26, 1.63) | 0.35 |
| DHFR 35289A | 25/41 | 17/47 | 0.03 | 2.99 (1.20, 7.55) | 0.02 |
| RFC 80A | 32/47 | 32/47 | 1.00 | 1.03 (0.43, 2.49) | 0.94 |