Studies identifying cardiovascular disease and risk factors in patients with psoriasis.
| Study | Design | Findings |
|---|---|---|
| McDonald5 | Clinic-based control study of 323 patients and 325 controls | Higher rates (2.2) of occlusive vascular disease in patients with psoriasis compared to controls |
| Gelfand6 | Retrospective, population-based cohort study based on the UK General Practice Research Database (130,976 patients) | Increased rates of diabetes, obesity, hypertension, hyperlipidemia, and smoking in patients with psoriasis |
| Kaye7 | Retrospective Cohort Study based on the UK General Practice Research Database (44,164 patients) | Increased rates of myocardial infarction, angina, and peripheral vascular disease, also increased diabetes, smoking, hypertension, and hyperlipidemia |
| Brauchli8 | Cohort study of 36,702 patients from UK General Practice database | Found no increased risk for myocardial infarction overall but, in patients < 60 yrs with severe disease, risk was increased |
| Lindegard9 | Retrospective review of database (2941 patients) | Increased rates of hypertension and diabetes and myocardial infarction in women with psoriasis |
| Henseler10 | Retrospective cohort identified from dermatology database (42,461 patients) | Increased rates of cardiovascular disease, diabetes, obesity and hypertension |
| Poikolainen11 | Retrospective review of patients identified from in-patient registry (5687 patients) | Increased rates of cardiovascular disease in men and women (M 1.49, F 1.7) |
| Mallbris12 | Retrospective cohort study from Inpatient Registry and Psoriasis Association (8991 patients and 19,757 outpatients) | Increased risk of death from cardiovascular disease of 1.86 for inpatients and 0.94 for outpatients |
| Shapiro13 | Retrospective cross-sectional study based on an Israeli database (46,095 patients) | Increased rates of atherosclerosis and diabetes in psoriasis |
| Kimball14 | Retrospective case control study of 2 US healthcare databases (46,170 patients) | Increased cardiovascular disease and diabetes |