Laboratory values.
| Measurement | Patient 1 | Patient 2 |
|---|---|---|
| Leukocytes/mm3 (× 103) | 4.4 | 6.4 |
| Hemoglobin, g/dl | 10.7 | 12.1 |
| Platelets/mm3 (× 103) | 303 | 360 |
| ESR, mm/h | 81 | 80 |
| CRP, mg/l, normal < 5 | ND | 10 |
| RF, IU/ml, normal < 20 | 25.8 | < 20 |
| Anti-CCP | ND | Negative |
| C3 and C4 | Normal | ND |
| Cryoglobulins | Negative | ND |
| Chlamydia PCR, synovium | Negative | Negative |
| HIV, HBV serology | Negative | Negative |
| Viral load, copies/ml | > 1 × 106* | 1.5 × 105† |
| 5.3 × 106** | 6.3 × 105†† | |
| HCV genotype | 1A | 1B |
| SF cell count, leukocytes/mm3 | 6050 | 50,715 |
↵* Two years before biopsy;
↵** 3 years after biopsy;
↵† 1 year before biopsy;
↵†† 2 years after biopsy. C3 and C4: complement components 3 and 4; CCP: cyclic citrullinated peptide; CRP: C-reactive protein; ESR: erythrocyte sedimentation rate; HBV: hepatitis B virus; HIV: human immunodeficiency virus; ND: not determined; RF: rheumatoid factor; SF: synovial fluid; PCR: polymerase chain reaction; HCV: hepatitis C virus.