Demographic data of clinical population groups.
| Characteristics | Controls, n = 31 | Healthy Hyperuricemia, n = 15 | Acute Gout, n = 29 | Chronic Gout, n = 16 | Entire Cohort, n = 91 | p |
|---|---|---|---|---|---|---|
| Age, yrs, median (IQR) | 63 (50–68) | 60 (58–63) | 60 (52–67) | 64.5 (54–70.5) | 61 (54–68) | 0.88 |
| Male:female (% male) | 30:1 (97) | 14:1 (93.3) | 28:1 (97) | 15:1 (93.4) | 87.4 (95.6) | |
| White, n (%) | 31 (100) | 14 (93.3) | 24 (82.8) | 14 (87.5) | 83 (89) | |
| BMI, median (IQR) | 25.9 (24.3–28.1) | 29.2 (27–33.4) | 28.5 (25.6–32.1) | 27.3 (25.4–32.4) | 27.2 (25.4–31.4) | 0.01 |
| Serum urate, mmol/l, median (IQR) | 0.34 (0.33–0.37) | 0.45 (0.42–0.47) | 0.44 (0.42–0.47) | 0.47 (0.45–0.51) | 0.42 (0.36–0.47) | 0.0001 |
| Serum CRP, mg/l, median (IQR) | 1 (1–2) | 1 (1–2) | 2 (1–3) | 2 (1.5–6.5) | 1 (1–3) | 0.05 |
| Treated hypertension, n (%) | 3 (10) | 8 (29) | 16 (55) | 7 (44) | 34 (37) | |
| Diabetes mellitus, n (%) | 0 (0) | 0 (0) | 3 (10) | 0 (0) | 3 (3) | |
| Cardiovascular disease, n (%) | 1 (3) | 0 (0) | 6 (21) | 2 (13) | 9 (10) |
Statistical analysis by Kruskal-Wallis test with Mann-Whitney U test for posttest comparisons (significant p values at 0.0083), except* Fisher’s exact ratio. BMI data are p = 0.001 for healthy control vs healthy hyperuricemic. Serum urate data are p < 0.0001 for healthy control vs healthy hyperuricemia, acute gout, and chronic gout. IQR: interquartile range; BMI: body mass index; CRP: C-reactive protein.