Minimal important difference (MID) estimates for Health Assessment Questionnaire-Disability Index (HAQ-DI) and pain, fatigue, sleep, and global health 100 mm visual analog scale (VAS). HAQ-DI scored from 0 to 3; improved is −, worsening is +. For the VAS scales of pain, fatigue, sleep, and global health, 0 is no problem, 100 is worst ever; improved is −, worsened is +. MID is determined as the mean of those who are better or worse.
| Patient-rated Overall Status | HAQ-DI Change, mean (SD) | 95% CI | Pain VAS Change, mean (SD) | 95% CI | Fatigue VAS Change, mean (SD) | 95% CI | Sleep VAS Change, mean (SD) | 95% CI | Global Health Change, mean (SD) | 95% CI |
|---|---|---|---|---|---|---|---|---|---|---|
| Much better (n = 10) | −0.250 (0.276) | −0.448, −0.052 | −14.60 (26.31) | −33.42, 4.22 | −14.30 (20.58) | −29.02, 0.42 | −19.30 (30.16) | −40.87, 2.27 | −8.60 (15.74) | −19.86, 2.66 |
| Better (n = 35) | −0.136 (0.228) | −0.214, −0.058 | −6.83 (27.14) | −16.15, 2.50 | −1.43 (29.18) | −11.45, 8.60 | −2.23 (29.35) | −12.31, 7.85 | −4.03 (15.13) | −9.23, 1.17 |
| Same (n = 58) | 0.005 (0.263) | −0.064, 0.074 | −2.03 (22.77) | −8.02, 3.95 | −1.90 (19.92) | −7.13, 3.34 | −3.29 (21.16) | −8.86, 2.27 | −6.09 (18.29) | −10.89, −1.28 |
| Worse (n = 33) | 0.220 (0.354) | 0.094, 0.345 | 18.97 (27.00) | 9.40, 28.54 | 14.42 (20.45) | 7.17, 21.67 | 10.76 (28.94) | 0.50, 21.02 | 16.85 (18.90) | 10.15, 23.55 |
| Much worse (n = 4) | 0.531 (0.483) | −0.237, 1.299 | 15.00 (4.76) | 7.42, 22.58 | 10.75 (14.91) | −12.97, 34.47 | −5.50 (5.26) | −13.87, 2.87 | 8.50 (11.82) | −10.31, 27.31 |