Variable | Responsive, n = 76 | Refractory, n = 23 | p |
---|---|---|---|
Age, average (range), yrs | 9.3 (2–18) | 10.8 (3–17) | 0.09 |
Male/female | 52/24 | 16/7 | 0.99 |
Characteristics of early disease | |||
Erythema migrans, no (%) | 6 (8) | 0 (0) | 0.33 |
Flu-like illness, no. (%) | 21 (28) | 7 (30) | 0.80 |
Arthritis as presentation, no. (%) | 68 (90) | 22 (96) | 0.68 |
Fevers, no. (%) | 25 (33) | 5 (22) | 0.44 |
Neurologic involvement, no. (%) | 1 (1) | 2 (9) | 0.13 |
Characteristics of arthritis | |||
Joint count, median (interquartile range, full range) | 1 (1–2, 1–6) | 1 (1–1, 1–2) | 0.16 |
Duration of arthritis prior to antibiotic therapy, median (interquartile range, full range) weeks | 2 (1–4.5, 0–52) | 3 (2–6, 1–32) | 0.74 |
Initial antibiotic used, amoxicillin/doxycycline* | 37/31 | 11/12 | 0.63 |
Additional antibiotics used, oral only/intravenous** | 2/4 | 8/15 | 1 |
↵* Missing n = 8. In these patients, the initial antibiotic was neither amoxicillin nor doxycycline, but other cephalosporins, ceftriaxone, or unspecified antibiotics.
↵** Total n = 29, representing 23 patients with refractory arthritis who did not respond to additional antibiotic therapy and 6 patients with persisting arthritis who did respond to the additional course.