Association between 6q23 rs6920220 genotypes and typical disease features in patients with GCA.
| Disease Features | 6q23 rs6920220 | With, n (%) | Without, n (%) | p | OR (95% CI) |
|---|---|---|---|---|---|
| PMR | AA | 4 (3.9) | 4 (3.5) | 1.00 | 1.12 (0.23–5.51) |
| AG | 32 (31.4) | 35 (30.7) | 0.92 | 1.03 (0.56–1.91) | |
| GG | 66 (64.7) | 75 (65.8) | 0.87 | 0.95 (0.52–1.74) | |
| A | 40 (19.6) | 43 (18.9) | 0.84 | 1.05 (0.63–1.74) | |
| G | 164 (80.4) | 185 (81.1) | 0.84 | 0.95 (0.57–1.58) | |
| Visual manifestations | AA | 1 (1.9) | 7 (4.3) | 0.68 | 0.42 (0.02–3.51) |
| AG | 18 (33.3) | 49 (30.2) | 0.67 | 1.15 (0.57–2.34) | |
| GG | 35 (64.8) | 106 (65.4) | 0.93 | 0.97 (0.49–1.95) | |
| A | 20 (18.5) | 63 (19.4) | 0.83 | 0.94 (0.52–1.70) | |
| G | 88 (81.5) | 261 (80.6) | 0.83 | 1.06 (0.59–1.93) | |
| Severe ischemic manifestations | AA | 4 (3.4) | 4 (4.0) | 1.00 | 0.84 (0.17–4.13) |
| AG | 36 (30.8) | 31 (31.3) | 0.93 | 0.97 (0.53–1.81) | |
| GG | 77 (65.8) | 64 (64.6) | 0.85 | 1.05 (0.58–1.92) | |
| A | 44 (18.8) | 39 (19.7) | 0.81 | 0.94 (0.57–1.57) | |
| G | 190 (81.2) | 159 (80.3) | 0.81 | 1.06 (0.64–1.76) |
GCA: giant cell arteritis; PMR: polymyalgia rheumatica.