Frequencies of MMP2 alleles and genotypes in SSc, in the diffuse cutaneous subset, in SSc patients with fibrosing alveolitis and controls. Data are no. (%).
| Feature | SSc | dcSSc | FA | Controls | p* | |
|---|---|---|---|---|---|---|
| rs-1306 prom | ||||||
| Allele | C | 1364 (78) | 467 (78) | 542 (78) | 1544 (76) | 0.24 |
| T | 392 (22) | 129 (22) | 156 (22) | 486 (24) | ||
| Genotypes | CC | 535 (61) | 187 (63) | 217 (62) | 596 (59) | 0.3 |
| TC | 294 (33) | 93 (31) | 108 (31) | 352 (35) | ||
| TT | 49 (6) | 18 (6) | 24 (7) | 67 (6) | ||
| rs-790 prom | ||||||
| Allele | T | 1341 (78) | 467 (79) | 533 (78) | 1529 (76) | 0.22 |
| G | 377 (22) | 113 (21) | 147 (22) | 720 (24) | ||
| Genotypes | TT | 528 (61) | 183 (63) | 214 (63) | 592 (59) | 0.28 |
| TG | 285 (33) | 91 (31) | 105 (31) | 345 (34) | ||
| GG | 46 (6) | 16 (6) | 21 (6) | 64 (7) | ||
| rs-735 prom | ||||||
| Allele | C | 1518 (87) | 521 (89) | 613 (89) | 1752 (88) | 0.62 |
| T | 216 (13) | 67 (11) | 73 (11) | 236 (12) | ||
| Genotypes | CC | 669 (77) | 232 (79) | 274 (80) | 769 (77) | 0.35 |
| TC | 188 (22) | 57 (19) | 65 (19) | 214 (22) | ||
| TT | 14 (1) | 5 (2) | 4 (1) | 11 (1) | ||
| rs1292301 | ||||||
| Allele | C | 1135 (65) | 399 (68) | 460 (65) | 1326 (65) | 0.84 |
| T | 611 (35) | 191 (32) | 232 (35) | 704 (35) | ||
| Genotypes | CC | 372 (43) | 136 (46) | 153 (44) | 436 (43) | 0.83 |
| TC | 391 (45) | 127 (43) | 154 (44) | 454 (45) | ||
| TT | 110 (12) | 32 (11) | 39 (12) | 125 (12) | ||
| rs7201 | ||||||
| Allele | A | 972 (56) | 330 (57) | 385 (56) | 1090 (55) | 0.58 |
| C | 760 (44) | 250 (43) | 299 (44) | 884 (45) | ||
| Genotypes | AA | 285 (33) | 101 (35) | 111 (32) | 313 (32) | 0.61 |
| AC | 402 (46) | 128 (44) | 163 (48) | 464 (47) | ||
| CC | 179 (21) | 61 (21) | 68 (20) | 210 (21) | ||
| rs243849 | ||||||
| Allele | C | 1445 (83) | 488 (83) | 585 (85) | 1650 (83) | 0.77 |
| T | 299 (17) | 100 (17) | 103 (15) | 350 (17) | ||
| Genotypes | CC | 602 (69) | 205 (70) | 251 (73) | 686 (69) | 0.74 |
| TC | 241 (28) | 78 (27) | 83 (24) | 278 (28) | ||
| TT | 29 (3) | 11 (3) | 10 (3) | 36 (3) | ||
↵* Comparison of frequencies of minor allele and homozygous genotype between SSc and controls. dcSSc: diffuse cutaneous systemic sclerosis; FA: SSc patients with fibrosing alveolitis.