Table 1

Baseline characteristics at the first visit according to %dUA quartiles.

%dUA Quartile
VariablesTotal, nFirst (range -47.2/–7.5)Second (range –7.4/–1.2)Third (range 0.0/7.1)Fourth (range 7.2/77.8)p for Trend
Women/men1185/1968290/496252/483327/514316/475
Baseline data at visit 1
  Age, yrs52.8 ± 10.252.6 ± 10.653.3 ± 10.152.9 ± 10.052.3 ± 10.20.225
  Waist circumference, cm82.3 ± 9.282.8 ± 9.682.7 ± 9.182.2 ± 8.781.7 ±9.30.074
  Body mass index, kg/m222.8 ± 3.123.0 ± 3.322.8 ± 3.022.8 ± 3.022.6 ± 3.10.056
  Systolic blood pressure, mmHg123 ± 19124 ± 20123 ± 19122 ± 19123 ± 190.636
  LDL-cholesterol, mg/dl129.1 ± 31.2130.2 ± 31.3129.4 ± 29.5129.8 ± 31.3126.9 ± 32.20.147
  HDL-cholesterol, mg/dl60.7 ± 15.360.7 ± 15.860.5 ± 15.560.8 ± 14.860.9 ± 15.10.980
  Triglyceride, mg/dl111 ± 72112 ± 75115 ± 81109 ± 67109 ± 650.249
  Uric acid, mg/dl5.5 ± 1.35.8 ± 1.55.7 ± 1.25.4 ± 1.35.1 ± 1.2< 0.001
  Fasting glucose, mg/dl96 ± 2197 ± 2096 ± 1995 ± 1896 ± 250.486
  Hemoglobin A1c, %5.3 ± 0.75.3 ± 0.75.3 ± 0.75.3 ± 0.75.3 ± 0.90.941
  Blood urea nitrogen, mg/dl14.1 ± 3.514.6 ± 4.014.3 ± 3.214.1 ± 3.313.6 ± 3.5< 0.001
  Serum creatinine, mg/dl0.77 ± 0.290.79 ± 0.420.78 ± 0.150.76 ± 0.150.75 ± 0.340.068
  Estimated glomerular filtration rate, ml/min/1.73m268.3 ± 11.867.3 ± 11.867.8 ± 11.568.1 ± 11.470.2 ± 12.4< 0.001
  Antihypertensive medication, n (%)306 (9.7)78 (9.9)78 (10.6)76 (9.0)74 (9.4)0.736
  Antidiabetic medication, n (%)74 (2.3)19 (2.4)14 (1.9)24 (2.9)17 (2.1)0.632
  Postmenopause (female), n (%)649 (54.8)152 (52.4)141 (56.0)194 (59.3)162 (51.3)0.165
  Current smoker, n (%)734 (23.3)180 (22.9)173 (23.5)197 (23.4)184 (23.3)0.992
Percent change between 2 visits
  %dBMI–0.28 ± 3.1–0.70 ± 3.41–0.46 ± 3.060.01 ± 2.88–0.03 ± 2.98< 0.001
  %dWC0.17 ± 6.12–0.02 ± 6.33–0.35 ± 6.140.64 ± 6.140.35 ± 5.830.008
  %deGFR1.8 ± 10.06.3 ± 10.02.6 ± 9.00.9 ± 9.1–2.5 ± 10.0< 0.001