Univariate and multivariate associations of plasma vitamin D [25(OH)-D] concentrations with rheumatoid arthritis (RA) baseline and 36-month measures of disease activity and severity in African Americans with recent-onset disease (n = 266).
| Measure of Disease | Univariate | Multivariate | ||
|---|---|---|---|---|
| ß-coefficient (95% CI) | p | ß-coefficient (95% CI) | p | |
| Pain (0–10), baseline | –0.24 (–0.46 to –0.02) | 0.04 | –0.18 (–0.41 to 0.06) | 0.14 |
| Pain (0–10),36-mo | –0.28 (–0.76 to 0.21) | 0.27 | –0.34 (–0.85 to 0.18) | 0.20 |
| HAQ (0–3), baseline | –0.05 (–0.12 to 0.02) | 0.15 | –0.04 (–0.12 to 0.03) | 0.28 |
| HAQ (0–3), 36-mo | –0.03 (–0.09 to 0.04) | 0.46 | –0.02 (–0.09 to 0.05) | 0.66 |
| Swollen joints (0–28), baseline | –0.49 (–0.96 to –0.02) | 0.04 | –0.40 (–0.90 to 0.10) | 0.11 |
| Swollen joints (0–28), 36-mo | –0.02 (–0.53 to 0.49) | 0.94 | 0.04 (–0.50 to 0.59) | 0.87 |
| Tender joints (0–28), baseline | –0.35 (–1.00 to 0.30) | 0.29 | –0.24 (–0.93 to 0.44) | 0.48 |
| Tender joints (0–28), 36-mo | –0.07 (–0.70 to 0.55) | 0.82 | –0.01 (–0.68 to 0.66) | 0.97 |
| hsCRP (mg/dl), baseline | –1.94 (–5.04 to 1.17) | 0.22 | –0.95 (–4.11 to 2.20) | 0.55 |
| DAS28, baseline | –0.11 (–0.23 to –0.0004) | 0.05 | –0.08 (–0.20 to 0.04) | 0.19 |
| OR (95% CI) | p | OR (95% CI) | p | |
| Anti-CCP antibody-positive | 1.07 (0.91 to 1.27) | 0.42 | 1.14 (0.95 to 1.37) | 0.15 |
| RF-IgM-positive | 1.06 (0.89 to 1.26) | 0.53 | 1.22 (1.00 to 1.49) | 0.05 |
| Radiographic erosions, baseline | 0.92 (0.73 to 1.15) | 0.44 | 0.87 (0.69 to 1.10) | 0.25 |
| Radiographic erosions, 36-mo | 0.82 (0.63 to 1.07) | 0.14 | 0.79 (0.60 to 1.04) | 0.09 |
| Subcutaneous nodules | 1.01 (0.81 to 1.26) | 0.92 | 0.92 (0.72 to 1.17) | 0.48 |
Multivariate analyses adjusted for age, gender, and season of study enrollment; in addition all 36-month outcomes (univariate and multivariate) adjusted for baseline value. Subjects included 266 patients with baseline data (including 184 with scored radiographs) and of these, 191 had data at 3 years’ disease duration (including 134 with scored radiographs). Dichotomous outcomes examined using logistic regression, continuous outcomes examined with linear regression. HAQ: Health Assessment Questionnaire; hsCRP: highly sensitive C-reactive protein; CCP: cyclic citrullinated peptide; RF: rheumatoid factor; DAS28: 3-variable Disease Activity Score using hsCRP and 28 tender/swollen joint counts.