Population | No. Subjects | TT n (%) | TC n (%) | CC n (%) | TC + CC n (%) | T allele (%) | p value* (p corr) | OR CI |
---|---|---|---|---|---|---|---|---|
Controls | 269 | 27 (10.0) | 94 (34.9) | 148 (59.8) | 242 (90.0) | 27.50 | ||
SSc patients | 241 | 6 (2.5) | 91 (37.8) | 144 (59.8) | 235 (97.5) | 21.36 | 0.001 (0.005) | 0.23 (0.09–0.56) |
dcSSc | 77 | 2 (2.6) | 28 (36.4) | 47 (61.0) | 75 (97.4) | 20.78 | 0.001 (0.005) | 0.23 (0.09–0.56) |
lcSSc | 156 | 4 (2.6) | 58 (37.2) | 94 (60.2) | 152 (97.4) | 21.15 | 0.008 (0.043) | 0.24 (0.08–0.69) |
SSc: systemic sclerosis; dcSSc: diffuse cutaneous SSc; lcSSc: limited cutaneous SSc. CI: confidence interval. P value: univariate analyses were performed to compare genotype frequencies (TT vs TC + CC) between cases and controls. p corr: p values were corrected according to the method for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other17,18. Hardy-Weinburg equilibrium test was done on control group. The obtained value (0.13) was not significant. The selected cutoff p value was 0.001.