Clinical and laboratory data in patients with SLE and controls.
| Characteristic | Patients, n = 47 | Controls, n = 21 | p |
|---|---|---|---|
| Age, yrs | 38 ± 12 (18–60) | 34 ± 12 (18–57) | 0.17 |
| Female, % | 94 | 90 | 0.64 |
| Nonhispanic whites and Hispanic, % | 36 and 55 | 38 and 48 | 0.81 |
| Body mass index, kg/m2 | 27 ± 6 | 26 ± 5 | 0.41 |
| Systolic blood pressure, mm Hg | 125 ± 14 | 117 ± 9 | 0.008 |
| Diastolic blood pressure, mm Hg | 77 ± 10 | 73 ± 6 | 0.05 |
| Mean arterial blood pressure, mm Hg | 93 ± 10 | 88 ± 6 | 0.01 |
| Smoking*, % | 53 | 24 | 0.03 |
| Hemoglobin, g/dl | 13.3 ± 1.6 | 14 ± 1.5 | 0.04 |
| Platelets, k/mm3 | 251 ± 96.7 | 268 ± 41 | 0.36 |
| White blood cell count, k/mm3 | 5.6 ± 2.2 | 6.5 ± 1.8 | 0.08 |
| Cholesterol, mg/dl | 184 ± 45 | 185 ± 45 | 0.95 |
| Triglycerides, mg/dl | 153 ± 78 | 156 ± 103 | 0.91 |
| Creatinine, mg/dl | 0.83 ± 0.33 | 0.73 ± 0.11 | 0.05 |
| Proteinuria, mg/dl | 50 ± 117 | 3.5 ± 8 | 0.01 |
| Glucose, mg/dl | 90 ± 21 | 82.6 ± 9 | 0.13 |
| Albumin, g/dl | 3.9 ± 0.6 | 4.3 ± 0.3 | 0.007 |
| P-selectine, ng/ml | 42 ± 20.45 | 39 ± 16 | 0.49 |
| C3a, pg/ml | 2301 ± 3317 | 2096 ± 2218 | 0.77 |
| C5a, pg/ml | 31.6 ± 10.7 | 29 ± 9.8 | 0.37 |
| Quantitative D-dimer, μg/ml | 1.01 ± 3.2 | 0.33 ± 0.39 | 0.17 |
| tPA, ng/ml | 10.3 ± 6.6 | 7.6 ± 4.4 | 0.05 |
| PAI-1, U/ml | 9.7 ± 12.5 | 17.3 ± 37 | 0.36 |
| Peak thrombin generation, nmol/l | 390.8 + 133.5 | 440 ± 136.5 | 0.19 |
| Thrombin-antithrombin complexes, ng/ml | 7.5 ± 10 | 5.8 ± 7 | 0.45 |
| Platelet-derived CD41 microparticles, μl | 552.9 ± 668 | 517 ± 592 | 0.83 |
| Monocyte-derived CD41 microparticles, μl | 441.7 ± 668 | 476.7 ± 486.6 | 0.81 |
| Endothelium-derived CD144 microparticles, μl | 161.6 ± 235 | 154 ± 122 | 0.87 |
↵* Defined as any amount of smoking for any duration of time. tPA: tissue plasminogen antigen; PAI: plasminogen activator inhibitor.