Table 2.

IL-6-knockout in MRL-Faslpr mice had no effect on serum IgG subtype or dsDNA antibody levels. Serum IgG levels measured by ELISA. Levels of dsDNA antibodies were tested at the Laboratory of Clinical Chemistry, University Hospital Mainz. All data p > 0.05, Mann-Whitney test.

Antibodies
IgG1, mg/mlIgG2a, mg/mlIgG2b, mg/mlIgG3, mg/mldsDNA, IU/ml
IL-6 −/−1.8 ± 0.21.8 ± 0.61.2 ± 0.30.5 ± 0.212.9 ± 8.7
Controls1.4 ± 0.52.1 ± 0.50.8 ± 0.30.7 ± 0.311.2 ± 4.4