Table 6.

Disease activity and damage in early onset (< 50 yrs) vs late onset (≥ 50 yrs) SLE.

Early OnsetLate Onsetp
Mean SLAM score5.19 ± 3.867.07 ± 4.41< 0.0001*
Mean SLEDAI score4.29 ± 4.314.39 + 4.180.8
Mean no. with lupus flare over last year0.89 ± 0.981.04 ± 0.980.2
Mean disease activity (VAS)3.43 ± 2.814.11 ± 2.630.04*
Mean unusual fatigue (VAS)4.43 ± 3.234.73 ± 2.600.4
SLAQ, self-reported, %
  Rash/nausea after sun exposure33.548.70.05*
  Shortness of breath40.159.00.02*
  Numbness/tingling32.755.30.002*
  Muscle weakness52.864.60.0008*
  Mean SLICC score1.50 ± 1.941.80 ± 1.670.09
  • * Statistically significant. SLAM: SLE activity measure; SLEDAI: SLE Disease Activity Index; VAS: visual analog scale; SLAQ: SLE Activity Questionnaire; SLICC: Systemic Lupus International Collaborating Clinics.