Ultrasound and blood biomarker endpoints. Results are displayed as the geometric mean followed by the range (minimum–maximum) of the endpoints at baseline (Day 1), Day 8, and Day 15.
| Group | Variable | Day 1 (Baseline) | Day 8 | Day 15 |
|---|---|---|---|---|
| Low/remission RA | Synovial thickness index | 8.3 (4–15) | 8.6 (4–20) | 8.2 (4–22) |
| Synovial vascularity index | 6.2 (1–23) | 9.8 (4–23) | 10.1 (5–22) | |
| Power Doppler area | 1113.8 (21–16253) | 2309.1 (280–20854) | 2561.0 (353–18204) | |
| CRP, mg/l | 2.4 (1–23) | 3.2 (1–31) | 2.0 (1–14) | |
| VEGF, pg/ml | 80 (14–342) | 55 (5–293) | 56 (5–294) | |
| ESR, mm/h | 7.5 (3–29) | 10.2 (3–29) | 8.9 (4–21) | |
| High/moderate RA | Synovial thickness index | 11.1 (3–21) | 12.3 (4–22) | 12.7 (8–20) |
| Synovial vascularity index | 11.2 (3–31) | 12.4 (0–27) | 7.8 (1–25) | |
| Power Doppler area | 2540.1 (77–39308) | 1683 (2–32806) | 1828 (77–32350) | |
| CRP, m/l | 5.5 (2–20) | 4.6 (1–17) | 5.7 (2–44) | |
| VEGF, pg/ml | 104 (12–26) | 89 (5–3117) | 65 (5–850) | |
| ESR, mm/h | 20.6 (7–36) | 19.2 (8–36) | 17.4 (2–42) | |
| Corticosteroid | Synovial thickness index | 17.4 (12–26) | 16.2 (11–21) | 14.6 (10–20) |
| Synovial vascularity index | 20.3 (11–34) | 12.6 (3–30) | 12.2 (4–24) | |
| Power Doppler area | 23781.7 (7599–68846) | 12377.7 (752–67103) | 10769.4 (472–50047) | |
| CRP, m/l | 9.6 (4–30) | 5.3 (1–26) | 6.4 (2–36) | |
| VEGF, pg/ml | 30 (5–393) | 39 (5–288) | 46 (12–399) | |
| ESR, mm/h | 22.8 (5–49) | 14.7 (2–33) | 16.9 (2–34) | |
| OA | Synovial thickness index | 3.2 (1–7) | 4.5 (2–12) | 4.5 (2–13) |
| Synovial vascularity index | 7.6 (2–14) | 8.3 (3–21) | 9.2 (3–16) | |
| Power Doppler area | 2051.6 (1097–6182) | 2265.3 (721–7379) | 2114.5 (94–6923) | |
| CRP, m/l | 1.6 (1–4) | 1.4 (1–3) | 1.5 (1–5) | |
| VEGF, pg/ml | 30 (5–97) | 23 (5–209) | 21 (5–298) | |
| ESR, mm/h | 9.3 (4–25) | 8.8 (2–30) | 7.2 (2–30) |
CRP: C-reactive protein; ESR: erythrocyte sedimentation rate; VEGF: vascular endthelial growth factor.