ACR and PsARC results using the derived models.
| Response Index | Cutoff Point | Sensitivity | Specificity | Logistic Regression (LR) Models | |||||
|---|---|---|---|---|---|---|---|---|---|
| Estimate | SE | z | Residual Deviance | Residual Degrees of Freedom | Area Under ROC Curve | ||||
| LR-PsARC index* | 480.5 | 417 | 0.78 | ||||||
| Intercept | −1.27 | 0.24 | −5.20 | ||||||
| PC30 JNT IMPR | 0.87 | 0.28 | 3.08 | ||||||
| MDGDA-1 cat | −0.85 | 0.20 | −4.23 | ||||||
| PtGDA-1 cat | −0.69 | 0.17 | −4.04 | ||||||
| LR-PsARCc1 | 0.289 | 0.79 | 0.68 | 2.07 | 0.22 | 9.24 | 485.5 | 419 | |
| LR-PsARCc2 | 0.033 | 0.81 | 0.66 | 2.12 | 0.23 | 9.31 | 482.6 | 419 | |
| LR-ACR20 index** | 442.1 | 414 | 0.82 | ||||||
| Intercept | −2.39 | 0.28 | −8.55 | ||||||
| PC201 JNT | 0.69 | 0.25 | 2.76 | ||||||
| PC201 CRP | 1.24 | 0.25 | 5.06 | ||||||
| PC201 MDGDA | 1.09 | 0.26 | 4.13 | ||||||
| PC201 PTGDA | 0.19 | 0.30 | 0.64 | ||||||
| PC201 PTASSPAIN | 0.48 | 0.30 | 1.60 | ||||||
| PC201 HAQ | 0.58 | 0.25 | 2.27 | ||||||
| LR-ACR20c1 | 0.597 | 0.68 | 0.82 | 2.28 | 0.23 | 9.76 | 469.3 | 419 | |
| LR-ACR20c2 | 0.076 | 0.74 | 0.73 | 2.05 | 0.22 | 9.27 | 485.3 | 419 | |
| LR-ACR30 index*** | 414.4 | 414 | 0.84 | ||||||
| Intercept | −2.28 | 0.26 | −8.84 | ||||||
| PC301 JNT | 0.82 | 0.27 | 3.07 | ||||||
| PC301 CRP | 1.59 | 0.25 | 6.34 | ||||||
| PC301MDGDA | 1.00 | 0.28 | 3.62 | ||||||
| PC301PtGDA | 0.58 | 0.37 | 1.57 | ||||||
| PC301 PtASSPAIN | 0.25 | 0.36 | 0.68 | ||||||
| PC301 HAQ | 0.51 | 0.27 | 1.92 | ||||||
| LR-ACR30c1 | 0.872 | 0.63 | 0.89 | 2.65 | 0.27 | 9.98 | 449.4 | 419 | |
| LR-ACR30c2 | 0.135 | 0.73 | 0.84 | 2.63 | 0.24 | 10.79 | 437.3 | 419 | |
| LR-ACR40 index† | 393.7 | 414 | 0.86 | ||||||
| Intercept | −2.08 | 0.24 | −8.78 | ||||||
| PC401 JNT | 0.79 | 0.28 | 2.86 | ||||||
| PC401 CRP | 1.95 | 0.26 | 7.63 | ||||||
| PC401 MDGDA | 1.10 | 0.30 | 3.62 | ||||||
| PC401 PtGDA | −0.57 | 0.48 | −1.19 | ||||||
| PC401 PTASSPAIN | 1.50 | 0.46 | 3.24 | ||||||
| PC401 HAQ | 0.82 | 0.28 | 2.87 | ||||||
| LR-ACR40c1 | 1.185 | 0.54 | 0.95 | 3.13 | 0.35 | 8.90 | 445.7 | 419 | |
| LR-ACR40c2 | 0.224 | 0.72 | 0.83 | 2.53 | 0.24 | 10.50 | 447.0 | 419 | |
↵* PC30 JNT SWELL CNT — Joint swelling count: improvement = decrease by at least 30%, worsening = increase by at least 30%, otherwise same. PC30 JNT PAIN CNT — Joint pain/tenderness count: improvement = decrease by at least 30%, worsening = increase by at least 30%, otherwise same. PC30 JNT IMPR = (Improvement in PC30 JNT SWELL CNT) or (Improvement in PC30 JNT PAIN CNT). MDGDA — 1 cat — Physician global assessment of articular disease (disease activity): improvement = decrease by at least one category (−1), worsening = increase by at least one category (1), same = no category change (0). PTGDA-1 cat— Patient global assessment of articular disease (disease activity): improvement = decrease by at least one category (−1), worsening = increase by at least one category (1), same = no category change (0).
↵** PC201 JNT SWELL, PC201 JNT PAIN, PC201 CRP, PC201 MDGDA, PC201 PTGDA, PC201 PTASSPAIN, and PC201 HAQ are indicators for at least 20% improvement in swollen joint count, tender/painful joint count. C-reactive protein (CRP) measurement, physician global assessment of disease activity, patient global assessment of disease activity, patient assessment of pain and Health Assessment Questionnaire (HAQ) score. PC201 JNT = (PC201 JNT SWELL = 1) and (PC201 JNT PAIN = 1).
↵*** PC301 JNT SWELL, PC301 JNT PAIN, PC301 CRP, PC301 MDGDA, PC301 PTGDA, PC301 PTASSPAIN, and PC301 HAQ are indicators for at least 30% improvement in swollen joint count, tender/painful joint count, C-reactive protein measurement. Physician global assessment of disease activity. Patient global assessment of disease activity. Patient assessment of pain and HAQ score. PC301 JNT = (PC301 JNT SWELL = 1) and (PC301 JNT PAIN =1).
↵† PC401 JNT SWELL, PC401 JNT PAIN, PC401 CRP, PC401 MDGDA, PC401 PTGDA, PC401 PTASSPAIN, and PC401 HAQ are indicators for at least 40% improvement in swollen joint count, tender/painful joint count, CRP measurement, Physician global assessment of disease activity. Patient global assessment of disease activity, patient assessment of pain and HAQ score. PC401 JNT = (PC401 JNT SWELL = 1) and (PC401 JNT PAIN = 1).