Lipid and lipoprotein concentrations by nuclear magnetic resonance, segregated by APOE genotype.
| Variable | Genotype | p | ||
|---|---|---|---|---|
| E2 | E3 | E4 | ||
| n (%) | 12 (17.65) | 44 (64.70) | 12 (17.65) | |
| Mean IMT, mm* | 0.774 (0.198) | 0.646 (0.149) | 0.652 (0.180) | NS |
| Max IMT, mm* | 1.216 (0.473) | 0.962 (0.276) | 0.923 (0.251) | 0.041 |
| Lipid concentrations | ||||
| Tryglicerides, mmol/l† | 1.040 (0.738–1.638) | 0.845 (0.493–1.225) | 0.940 (0.630–1.098) | NS |
| Chol total, mmol/l* | 4.625 (0.978) | 4.952 (1.120) | 5.084 (1.163) | NS |
| LDLc, mmol/l* | 2.583 (0.633) | 2.843 (0.824) | 3.046 (0.930) | NS |
| HDLc, mmol/l* | 1.511 (0.280) | 1.682 (0.436) | 1.622 (0.323) | NS |
| ApoA1, mg/dl* | 141.670 (10.500) | 146.430 (13.881) | 144.830 (14.727) | NS |
| ApoB100, mg/dl* | 82.000 (18.616) | 87.550 (23.371) | 91.580 (24.678) | NS |
| Ratio apoB100/A1* | 0.580 (0.132) | 0.604 (0.177) | 0.630 (0.157) | NS |
| hsCRP, mg/dl† | 1.785 (1.193–5.858) | 1.370 (0.533–3.885) | 1.185 (0.575–3.415) | NS |
| Lp(a), mg/dl† | 6.300 (2.100–40.975) | 14.100 (7.300–31.900) | 22.000 (10.125–72.225) | NS |
| VLDL and chylomicron (Qm) particle concentrations | ||||
| VLDL and Qm, nmol/l* | 64.092 (42.228) | 47.148 (44.538) | 42.750 (28.292) | NS |
| Large VLDL and Qm, nmol/l* | 1.842 (2.390) | 0.871 (1.796) | 1.000 (1.010) | NS |
| Medium VLDL, nmol/l* | 25.117 (20.527) | 17.409 (24.157) | 13.625 (10.747) | NS |
| Small VLDL, nmol/l* | 37.150 (22.910) | 28.861 (24.311) | 28.108 (19.186) | NS |
| IDL particle concentrations | ||||
| IDL, nmol/l* | 93.917 (92.534) | 31.800 (39.257) | 37.500 (60.089) | 0.005 |
| LDL particle concentrations | ||||
| LDL total, nmol/l* | 1221.583 (295.917) | 1080.523 (395.368) | 1120.750 (452.542) | NS |
| Large LDL total, nmol/l* | 324.750 (123.302) | 597.614 (241.853) | 624.833 (249.356) | < 0.0001 |
| Small LDL total, nmol/l* | 803.167 (268.524) | 451.159 (403.012) | 458.333 (516.187) | 0.029 |
| Medium small LDL, nmol* | 170.167 (59.165) | 94.636 (84.334) | 96.500 (101.928) | 0.023 |
| Very small LDL, nmol/l* | 633.083 (211.933) | 356.455 (323.084) | 361.917 (414.583) | 0.033 |
| HDL particle concentrations | ||||
| HDL total, μmol/l* | 33.958 (4.137) | 31.336 (5.765) | 30.425 (5.902) | NS |
| Large HDL, μmol/l* | 7.392 (2.962) | 9.930 (3.847) | 9.667 (3.118) | NS |
| Medium HDL, μmol/l* | 4.458 (2.615) | 2.048 (2.560) | 2.133 (1.571) | 0.009 |
| Small HDL, μmol/l* | 22.100 (4.046) | 19.359 (5.143) | 18.625 (6.014) | NS |
| Mean particle size | ||||
| VLDL, nm* | 45.108 (6.113) | 52.218 (12.344) | 52.692 (9.913) | NS |
| LDL, nm* | 20.733 (0.425) | 21.768 (0.823) | 21.775 (0.882) | < 0.0001 |
| HDL, nm* | 8.900 (0.283) | 9.457 (0.500) | 9.425 (0.512) | 0.002 |
| Remnant lipoprotein cholesterol (RPLc) | ||||
| RLPc, mg/dl† | 4.059 (3.515–10.219) | 4.295 (3.219–5.706) | 3.688 (2.543–5.673) | NS |