Table 2.

Changes in study variables according to study time and setting.

VariableTrial Start, mean (SD)Trial End, mean (SD)Post-trial Followup
Positive ES (95% CI)Mean (SD)Negative ES (95% CI)
ACR20 (%)63.1
ACR50 (%)43.4
ACR70 (%)20.2
HAQ, 0–31.21 (0.60)0.71 (0.61)0.83 (0.72, 0.95)1.01 (0.71)0.44 (0.60, 0.26)
Global, 0–105.2 (2.3)2.5 (2.1)1.22 (1.07, 1.38)3.4 (2.5)0.38 (0.49, 0.25)
Pain, 0–105.8 (2.3)2.8 (2.4)1.29 (1.12, 1.45)3.5 (2.7)0.30 (0.41, 0.19)
Fatigue, 0–105.7 (2.7)3.1 (2.7)0.93 (0.78, 1.09)4.3 (2.9)0.41 (0.54, 0.27)
  • Trial start: pretreatment; trial end: 6 months later; post-trial followup: 0.8 years later. Differences between trial end and trial followup are significant at p < 0.001. Positive: clinical improvement; negative: clinical worsening; ES: effect size.