Table 4.

Validation of echo in PAH-SSc according to the OMERACT filter.

OMERACT Filter CriterionValidationHighest Quality of PAH Definition
Truth
  Face validityVNA
  Content validityNVA1
  Criterion validityPVA2
  Construct validityPVA1*/A2
Discrimination
  Sensitivity to change over timeNDNo studies
  Discrimination capacity over treatmentNDNo studies
  Reliability (reproducibility)PVB2
FeasibilityUA2
  • * For some aspects of construct validity only (association between pericardial effusion and mortality, tricuspid regurgitant jet velocity, and dyspnea). V: valid: A criterion was judged validated if appropriate information was available from studies including exclusively PAH-SSc patients (quality definition A1, see Table 1). Exception is face validity, which is evaluated by the judgement of experts as an appropriate measure rather than by specific studies. NV: not valid: Similarly, a criterion was judged not valid if appropriate information was available from studies including exclusively PAH-SSc patients (quality definition A1). PV: partially validated: A criterion was judged partially validated if data from studies lower than quality level A1 indicated that the criterion was validated. U: unclear, possibly not valid: A criterion was judged unclear/possibly not valid if data from studies lower than quality level A1 indicated that the criterion was not valid. NA: not applicable; ND: no data.