Adjusted hazard ratios (HR) of radiographic OA (rOA) and chronic symptoms outcomes — shorter limb and longer limb versus no limb length inequality (LLI).
| No LLI | Shorter Limb | Longer Limb | |
|---|---|---|---|
| Incident knee rOA | |||
| Knees with outcome/knees at risk | 398/2612 | 13/63 | 7/59 |
| Adjusted* HR (95% CI) | 1.00 (reference) | 1.35 (0.77–2.35) | 0.79 (0.37–1.67) |
| Progressive knee rOA 1† | |||
| Knees with outcome/knee at risk | 405/1197 | 20/42 | 17/43 |
| Adjusted* OR (95% CI) | 1.00 (reference) | 1.40 (0.89–2.20) | 1.12 (0.69–1.82) |
| Progressive knee rOA 2** | |||
| Knees with outcome/knees at risk | 148/596 | 12/23 | 11/24 |
| Adjusted* OR (95% CI) | 1.00 (reference) | 2.04 (1.12–3.70) | 1.75 (0.94–3.23) |
| Incident knee symptoms | |||
| Knees with outcome/knees at risk | 463/1998 | 10/51 | 8/47 |
| Adjusted†† OR (95% CI) | 1.00 (reference) | 0.87 (0.45–1.68) | 0.78 (0.37–1.65) |
| Progressive knee symptoms | |||
| Knees with outcome/knees at risk | 195/510 | 11/26 | 7/24 |
| Adjusted†† OR (95% CI) | 1.00 (reference) | 2.50 (0.86–7.27) | 1.90 (0.57–6.35) |
| Incident hip rOA | |||
| Hips with outcome/hips at risk | 187/1898 | 9/62 | 3/57 |
| Adjusted* HR (95% CI) | 1.00 (reference) | 1.51 (0.74–3.11) | 0.61 (0.19–1.91) |
| Progressive hip rOA 1† | |||
| Hips with outcome/hips at risk | 189/2305 | 8/69 | 8/61 |
| Adjusted* OR (95% CI) | 1.00 (reference) | 1.35 (0.68–2.68) | 1.30 (0.60–2.83) |
| Progressive hip rOA 2** | |||
| Hips with outcome/hips at risk | 36/629 | 4/19 | 0/14 |
| Adjusted* OR (95% CI) | 1.00 (reference) | 3.75 (1.26–11.13) | — |
| Incident hip symptoms | |||
| Hips with outcome/hips at risk | 968/2572 | 35/71 | 34/71 |
| Adjusted†† OR (95% CI) | 1.00 (reference) | 1.22 (0.77–1.93) | 1.19 (0.73–1.93) |
| Progressive hip symptoms | |||
| Hips with outcome/hips at risk | 149/363 | 3/9 | 6/13 |
| Adjusted†† OR (95% CI) | 1.00 (reference) | 0.97 (0.13–7.46) | 0.94 (0.23–3.93) |
↵* Adjusted for baseline age, baseline BMI, sex, race, and joint problems (i.e., injury, surgery, or fracture).
↵† An increase of at least 1 K-L grade from T0 assessment to T1 assessment among individuals with at least K-L grade 1 at T0.
↵** An increase of at least 1 K-L grade from T0 assessment to T1 assessment among individuals with at least K-L grade 2 at T0.
↵†† Adjusted for baseline age, baseline BMI, sex, race, joint problems in same joint, and OA (presence of K-L grade at least 2) in same joint.