Table 2.

Unadjusted and adjusted hazard ratios (HR) of radiographic OA (rOA) and chronic symptoms outcomes, by joint site.

Limb Length Inequality PresentNo. Joints at RiskNo. Joints With OutcomeUnadjusted HR (95% CI)Adjusted* HR (95% CI)
Incident knee rOAYes122201.20 (0.72–2.00)1.08 (0.66–1.76)
No2612398
Progressive knee rOA 1Yes85371.70 (1.15–2.51)1.22 (0.82–1.80)
No1197405
Progressive knee rOA 2**Yes47242.84 (1.72–4.69)1.83 (1.10–3.05)
No328148
Incident knee symptomsYes98180.68 (0.42–1.09)0.83 (0.47–1.47)††
No1998463
Progressive knee symptomsYes50181.19 (0.66–2.15)1.13 (0.53–2.39)††
No510195
Incident hip rOAYes119121.27 (0.72–2.23)1.17 (0.66–2.07)
No1898187
Progressive hip rOA 1Yes130161.63 (0.96–2.76)1.32 (0.78–2.22)
No2305189
Progressive hip rOA 2**Yes3342.11 (0.60–7.37)1.34 (0.37–4.83)
No62936
Incident hip symptomsYes142691.20 (0.90–1.60)1.21 (0.82–1.77)††
No2572968
Progressive hip symptomsYes2271.15 (0.46–2.85)0.95 (0.23–3.94)††
No295117
  • * Adjusted for baseline age, baseline body mass index (BMI), sex, race, and joint problems (i.e., injury, surgery, or fracture).

  • An increase of at least 1K-L grade from T0 assessment to T1 assessment among individuals with at least K-L grade 1 at T0.

  • ** An increase of at least 1 K-L grade from T0 assessment to T1 assessment among individuals with at least K-L grade 2 at T0.

  • †† Adjusted for baseline age, baseline BMI, sex, race, joint problems in same joint, and OA (presence of K-L grade at least 2) in same joint.