Characteristic | Anti-Th/To, n = 8 | ACA, n = 67 | p |
---|---|---|---|
Demographic | |||
Female:male | 5:3 | 66:1 | 0.0006 |
Mean age, yrs (± SD) | 54.5 (± 17.9) | 66.6 (± 10.1) | 0.0046 |
Mean disease duration, yrs (± SD) | 8.5 (± 6.5) | 8.7 (± 5.9) | NS |
Limited SSc (lcSSc), % | 100 | 98.5 | NS |
Mean time from Raynaud’s phenomenon to SSc onset*, yrs (range) | 6 (1–24) | 9 (1–47) | NS |
Skin involvement, % | |||
Telangiectasia | 12.5 | 49 | 0.048 |
Puffy hands | 62.5 | 28 | NS |
Digital ulcers | 50 | 55 | NS |
Capillaroscopic changes | 100 | 79* | NS |
Calcinosis | 12.5 | 28 | NS |
Cardiopulmonary involvement, % | |||
Pericarditis | 25 | 4.5 | 0.028 |
Interstitial lung disease (by chest radiograph) | 38 | 4.5 | 0.044 |
Pulmonary arterial hypertension | 0 | 10 | NS |
Pulmonary function tests | |||
FVC onset, mean % ± SD | 95.3 ± 18.8 | 114.1 ± 18.6 | 0.0183 |
Last FVC, mean % ± SD | 97.2 ± 20.5 | 114.7 ± 20.2 | 0.0298 |
DLCO onset, mean % ± SD | 81.1 ± 17.2 | 74.4 ± 18.9 | NS |
Last DLCO, mean % ± SD | 68.7 ± 14.5 | 64.6 ± 16.3 | NS |
% of DLCO at onset vs at the last evaluation | p = 0.0925 | p < 0.0001 |
↵* Defined by onset of first non-Raynaud feature of SSc disease. NS: nonsignificant. FVC: forced vital capacity; DLCO: diffusion capacity for carbon monoxide.