Diclofenac Sodium Gel, n = 198 | Vehicle, n = 187 | p | |
---|---|---|---|
OARSI Response Rate, Dominant Hand, % | |||
Week | |||
1 | 55.6 | 41.7 | 0.008 |
2 | 59.1 | 50.3 | 0.06 |
4 | 62.6 | 50.3 | 0.013 |
6 | 64.1 | 55.1 | 0.054 |
8 | 65.7 | 56.7 | 0.06 |
| |||
Diclofenac Sodium Gel, n = 198 | Vehicle, n = 187 | p | |
| |||
OA Pain Intensity, Nondominant Hand, mean ± SD | |||
Baseline | 27.8 ± 17.9 | 30.2 ± 18.2 | |
Change from baseline to | |||
Week 1 | 4.5 ± 16.7 | 2.0 ± 18.3 | 0.014 |
Week 2 | 5.3 ± 18.1 | 3.6 = 19.6 | 0.06 |
Week 4 | 6.4 ± 18.2 | 4.1 ± 21.1 | 0.06 |
Week 6 | 6.7 ± 18.9 | 4.3 ± 21.3 | 0.048 |
Week 8 | 6.9 ± 19.7 | 5.7 ± 21.6 | 0.20 |
| |||
Diclofenac Sodium Gel, n = 195 | Vehicle, n = 181 | p | |
| |||
End-of-Study Global Rating of Efficacy, % | |||
Rating | |||
0 = poor | 22.6 | 29.3 | |
1 = fair | 12.3 | 16.0 | |
2 = good | 17.4 | 18.2 | |
3 = very good | 28.7 | 24.9 | |
4 = excellent | 19.0 | 11.6 | |
Mean ± SD | 2.09 ± 1.44 | 1.73 ± 1.41 | 0.008* |
↵* Based on least-squares mean difference from proportional odds logit model. OARSI: Osteoarthritis Research Society International.