Discriminatory ability of 5 computer programs in comparison with semiquantitative observer scoring in measuring change in joint space width in the monotherapy group and the COBRA therapy group of the COBRA trial, taking all measured joints into consideration. Published in part in a previous OMERACT report10. Since then, Duryea has completed the measurement by his program, one program (method D in10) was left out due to measurement failure, and a revised Sharp program was added. Data presented here include the mean change over all measured joints, but the type and number of joints measured per program differ.
| No. Patients Included* | Monotherapy, mm | COBRA Therapy, mm | t Test | p | |
|---|---|---|---|---|---|
| Change between baseline and 6 mo | |||||
| Angwin method | 105 | −0.068 (0.084) | −0.031 (0.073) | −2.466 | 0.015 |
| Duryea method** | 104 | −0.062 (0.077) | −0.011 (0.096) | −2.959 | 0.004 |
| Kauffman-Moens method** | 98 | −0.024 (0.041) | 0.001 (0.067) | −2.251 | 0.027 |
| Sharp-Hall method | 102 | −0.076 (0.148) | −0.028 (0.148) | −1.639 | 0.104 |
| Sharp revised method | 93 | −0.033 (0.143) | 0.005 (0.118) | −1.153 | 0.252 |
| Observed scoring (joint space only) | 107 | 1.580 (3.208) | 0.947 (1.929) | 1.253 | 0.213 |
| Change between baseline and 12 mo | |||||
| Angwin method | 107 | −0.088 (0.110) | −0.054 (0.094) | −1.743 | 0.084 |
| Duryea method** | 99 | −0.035 (0.168) | −0.038 (0.091) | 0.094 | 0.925 |
| Kauffman-Moens method** | 99 | −0.024 (0.054) | −0.012 (0.065) | −0.927 | 0.356 |
| Sharp-Hall method | 104 | −0.096 (0.151) | −0.029 (0.152) | −2.239 | 0.027 |
| Sharp revised method | 100 | −0.059 (0.132) | −0.012 (0.111) | −2.184 | 0.031 |
| Observed scoring (joint space only) | 107 | 3.122 (5.234) | 2.605 (4.682) | 0.537 | 0.592 |
| Change between baseline and 18 mo | |||||
| Angwin method | NA | NA | NA | NA | NA |
| Duryea method** | 103 | −0.071 (0.100) | −0.032 (0.157) | −1.493 | 0.139 |
| Kauffman-Moens method** | 100 | −0.037 (0.075) | −0.029 (0.078) | −0.521 | 0.603 |
| Sharp-Hall method | 104 | −0.111 (0.203) | −0.054 (0.175) | −1.548 | 0.125 |
| Sharp revised method | 97 | −0.067 (0.170) | −0.017 (0.134) | −1.605 | 0.112 |
| Observed scoring (joint space only) | 107 | 4.827 (6.905) | 4.026 (6.780) | 0.601 | 0.549 |