Rating (0–10 numerical scale) for the strength of evidence in support of each biomarker as reflecting structural damage based on a systematic literature search.
| Mean (SD) | Range | |
|---|---|---|
| CTX-II | 6.5 (1.2) | 4–8 |
| MMP3 | 4.5 (1.2) | 2–6 |
| RANKL | 3.2 (1.2) | 1–5 |
| OPG | 2.8 (1.3) | 0–5 |
| CTX-I | 3.8 (1.3) | 2–7 |
For definitions, see Table 1.