Components of metabolic syndrome and uric acid by estimated glomerular filtration rate (eGFR) of Modification of Diet in Renal Disease Stage of chronic kidney disease in adults aged 20–49 years. Hyperuricemia was defined as serum urate level > 7.7 mg/dl in men or > 6.6 mg/dl in women. Uric acid was converted from mg/dl to μmol/l by multiplying by 59.45. In the definition of metabolic syndrome, body mass index (BMI) ≥ 27.0 kg/m2 was changed to waist circumference23,43.
| All (n = 28,745) | I ≥ 90 (n = 25,912) | II 60–89 (n = 2767) | III 30–59 (n = 42) | IV 15–29 (n = 11) | V < 15 or dialysis (n = 13) | p | |
|---|---|---|---|---|---|---|---|
| e-GFR, mean ± SD | 109.1 ± 16.7 | 111.9 ± 14.7 | 84.2 ± 5.0 | 48.4 ± 8.6 | 20.8 ± 4.4 | 8.4 ± 2.6 | < 0.0001 |
| Male (%) | 17,478 (100) | 15,445 (88.3) | 1991 (11.4) | 29 (0.2) | 6 (0.03) | 7 (0.04) | < 0.0001 |
| Age, yrs | 40.8 ± 6.3 | 40.5 ± 6.4 | 43.9 ± 4.9 | 40.9 ± 5.8 | 43.7 ± 5.4 | 43.1 ± 4.4 | < 0.0001 |
| BMI, kg/m2 | 23.7 ± 3.7 | 23.6 ± 3.7 | 24.9 ± 3.5 | 25.8 ± 5.0 | 25.8 ± 4.2 | 21.3 ± 2.5 | < 0.0001 |
| SBP, mm Hg | 119.9 ± 17.1 | 119.6 ± 16.9 | 122.2 ± 17.7 | 141.8 ± 29.8 | 144.0 ± 30.2 | 148.2 ± 27.6 | < 0.0001 |
| DBP, mm Hg | 77.0 ± 11.0 | 76.7 ± 10.8 | 78.9 ± 11.8 | 93.5 ± 19.5 | 91.1 ± 16.9 | 97.1 ± 32.5 | < 0.0001 |
| Uric acid, mg/dl | 6.1 ± 1.6 | 6.1 ± 1.6 | 7.0 ± 1.7 | 8.6 ± 2.1 | 8.3 ± 2.3 | 7.7 ± 2.4 | < 0.0001 |
| Total cholesterol | 189.4 ± 35.1 | 188.3 ± 34.6 | 199.9 ± 37.1 | 221.0 ± 54.8 | 220.4 ± 60.2 | 177.9 ± 43.2 | < 0.0001 |
| Triglyceride | 128.2 ± 108.2 | 126.3 ± 108.2 | 144.6 ± 105.6 | 201.2 ± 122.1 | 203.0 ± 118.6 | 102.9 ± 58.3 | < 0.0001 |
| HDL-cholesterol | 53.9 ± 13.8 | 54.1 ± 13.9 | 51.9 ± 13.4 | 49.8 ± 18.5 | 44.7 ± 17.2 | 53.5 ± 22.4 | < 0.0001 |
| LDL-cholesterol | 110.8 ± 31.1 | 109.8 ± 30.6 | 120.0 ± 33.1 | 132.4 ± 49.8 | 137.7 ± 49.3 | 103.9 ± 33.2 | < 0.0001 |
| Glucose, mg/dl | 93.2 ± 21.4 | 93.2 ± 21.6 | 93.6 ± 19.3 | 101.8 ± 26.8 | 91.0 ± 7.2 | 87.1 ± 3.8 | 0.0608 |
| Hypertension (%) | 2148 (7.5) | 1837 (7.1) | 283 (10.2) | 19 (45.2) | 4 (36.4) | 5 (38.5) | < 0.0001 |
| Hyperuricemia (%) | 5822 (20.3) | 4734 (18.3) | 1040 (37.6) | 32 (76.2) | 8 (72.7) | 8 (61.5) | < 0.0001 |
| Metabolic syndrome (%) | 2192 (7.6) | 1860 (7.2) | 311 (11.2) | 17 (40.5) | 3 (27.3) | 1 (7.7) | < 0.0001 |
HDL-cholesterol: high-density lipoprotein-cholesterol; LDL-cholesterol: low-density lipoprotein-cholesterol (all in mg/dl). SBP: systolic blood pressure; DBP: diastolic blood pressure.