L/S BMC (g) | L/S BMD (g/cm2) | L/S Loss (%/yr)** | T/F BMC (g) | T/F BMD (g/cm2) | T/F Loss (%/yr)** | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Genotype | M | F | M | F | M | F | M | F | M | F | M | F |
11 | 77.23 | 56.95 | 1.07 | 0.96 | 0.65 | 0.34 | 48.31 | 32.40 | 1.04 | 0.90 | −0.08 | −0.53 |
12 | 84.19 | 68.40 | 1.14 | 1.10 | 0.80 | −0.10 | 53.35 | 34.96 | 1.10 | 0.95 | −0.33 | −0.68 |
22 | — | — | — | — | — | — | — | — | — | — | — | — |
P trend* | 0.14 | 0.001 | 0.15 | < 0.001 | 0.79 | 0.60 | 0.02 | 0.03 | 0.12 | 0.03 | 0.09 | 0.93 |
↵* Adjusted for age, BMI, cigarette and alcohol consumption, dietary calcium intake, physical activity, years since menopause, and HRT use.
↵** A negative figure denotes bone loss over the followup period. SNP: single nucleotide polymorphism; BMC: bone mineral content; BMD: bone mineral density; BMI: body mass index; HRT: hormone replacement therapy. L/S: lumbar spine; T/F: total femur.