Method | Mild or Absent, n = 30 | Cerebral Vasculopathy | p | |
---|---|---|---|---|
Moderate, n = 12 | Severe, n = 10 | |||
CT scan | ||||
Age at time of brain imaging, yrs | 48.3 ± 11.9 | 48.4 ± 11.6 | 63.7 ± 10.4 | 0.004 |
Digital ulcers | 12 (40) | 5 (42) | 3 (30) | 0.83 |
Digital infarcts | 3 (10) | 2 (17) | 1 (10) | 0.82 |
Hypertension | 3 (10) | 3 (25) | 3 (30) | 0.25 |
Diabetes mellitus | 1 (3) | 1 (8) | 0 (0) | 0.58 |
PAH | 3 (10) | 3 (25) | 5 (50) | 0.025 |
SRC | 1 (3) | 3 (25) | 3 (30) | 0.04 |
PAH and/or SRC | 3 (10) | 7 (58) | 8 (80) | < 0.0001 |
MRI | n = 14 | n = 28 | n = 10 | p |
Age at time of brain imaging, yrs | 44.0 ± 13.0 | 52.4 ± 10.7 | 59.3 ± 12.6 | 0.025 |
Digital ulcers | 5 (36) | 10 (36) | 2 (20) | 0.64 |
Digital infarcts | 0 (0) | 4 (14) | 1 (10) | 0.33 |
Hypertension | 0 (0) | 6 (21) | 1 (10) | 0.15 |
Diabetes mellitus | 0 (0) | 2 (7) | 0 (0) | 0.41 |
PAH | 1 (7) | 2 (7) | 5 (50) | 0.003 |
SRC | 0 (0) | 3 (11) | 2 (20) | 0.25* |
PAH and/or SRC | 1 (7) | 5 (18) | 7 (70) | 0.0009 |
↵* Test for trend: p = 0.097. PAH: pulmonary arterial hypertension; SRC: scleroderma renal crisis.