Characteristic | Patients, n = 87 |
---|---|
Age, mean ± SD, yrs | 55.2 ± 13.2 |
Disease duration, yrs, mean ± SD | 7.2 ± 7.5 |
Disease duration < 5 yrs, n (%) | 31 (35.6) |
Weight, kg, mean ± SD | 66.7 ± 11.6 |
Height, m, mean ± SD | 162.2 ± 8.8 |
FVC % predicted, mean ± SD | 97.3 ± 25 |
FVC < 75% predicted, n (%) | 26 (29.9) |
DLCO/AV % predicted, mean ± SD | 77.5 ± 17.2 |
DLCO/AV < 75% predicted, n (%) | 36 (41.4) |
Interstitial lung disease on HRCT, n (%) | 47 (54) |
sPAP by echocardiography, mmHg, mean ± SD | 32.4 ± 10 |
sPAP > 40 mmHg, n (%) | 12 (13.8) |
PAH by right-heart catheterization, n (%) | 7 (8) |
Left ventricular ejection fraction %, mean ± SD | 67.9 ± 5.3 |
Diastolic left ventricular dysfunction, n (%) | 27 (33.3) |
Left ventricular mass, g, mean ± SD | 160 ± 47 |
Active or healed digital ulcers, n (%) | 24 (27.6) |
Acroosteolysis, n (%) | 18 (21.2) |
Calcinosis, n (%) | 20 (23.5) |
Knee pain, n (%) | 34 (39) |
Hemoglobin, g/l, mean ± SD | 12.9 ± 1.3 |
Creatinine, μmol/l, mean ± SD | 72 ± 16.5 |
CRP, mg/l, mean ± SD | 7.4 ± 12.2 |
Creatine phosphokinase, IU/l, mean ± SD | 129 ± 290 |
Antinuclear antibodies > 1/160, n (%) | 65 (74.7) |
Medsger severity scale, n = 1–2; n = 3–4 | 53; 34 |
European activity score (EAS), mean ± SD | 1.77 ± 1.64 |
EAS > 3, n (%) | 15 (17.2) |
sHAQ, mean ± SD | 0.81 ± 0.62 |
sHAQ > 1, n (%) | 26 (37.7) |
DLCO: diffusion capacity for carbon monoxide; HRCT: high-resolution computed tomography; FVC: forced vital capacity; sPAP: systolic pulmonary artery pressure; PAH: pulmonary arterial hypertension; CRP: C-reactive protein; sHAQ: systemic sclerosis Health Assessment Questionnaire. AV: alveolar volume.