Table 2B.

Biomarker correlations at Week 16 by treatment group. Results for golimumab plus MTX are in bold type and below the diagonal; those for MTX alone are above the diagonal.

BiomarkerIL-18MMP-9TIMP-1SAAE-selectinCRP
IL-18NSNSNSNSNS
MMP-9NSNSNSNSNS
TIMP-1r = 0.310, p = 0.0007r = 0.208, p = 0.0256NSNSNS
SAANSNSNSNS(r = 0.610, p < 0.0009)
E-selectinr = 0.229, p = 0.0138NSr = 0.197, p = 0.0348r = 0.247, p = 0.0077
CRPr = 0.183, p = 0.0518NSNSr = 0.628, p < 0.0001r = 0.262, p = 0.0048
  • CRP: C-reactive protein; IL-18: interleukin-18; MMP-9: matrix metalloproteinase 9; MTX: methotrexate; NS: not significant; SAA: serum amyloid A; TIMP-1: tissue inhibitor of matrix metalloproteinase 1.