Diagnostic properties of anti-MCV, anti-CCP2, and RF assays using optimal cutoff values.
| Assay | Sensitivity, % | Specificity, % | PPV, % | NPV, % | AUC | 95% CI | p |
|---|---|---|---|---|---|---|---|
| Anti-MCV | 78.2 | 93.4 | 93.7 | 77.4 | 0.93 | 0.89–0.95 | < 0.05 |
| Anti-CCP2 | 61.8 | 96.3 | 95.5 | 66.8 | 0.85 | 0.80–0.89 | < 0.05 |
| RF | 72.4 | 80.1 | 82.0 | 69.9 | 0.74 | 0.68–0.80 | < 0.05 |
CI: confidence interval; MCV: mutated citrullinated vimentin; CCP: cylic citrullinated peptide; RF: rheumatoid factor; PPV/NPV: positive/negative predictive value; AUC: area under the curve.