Anakinra (50–150 mg/kg) vs placebo, ACR 20/50/70 at 24 wks.
| ACR20 | ACR50 | ACR70 | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Study (Reference) | Anakinra n/N (%) | Placebo n/N (%) | NNT | Anakinra n/N (%) | Placebo n/N (%) | NNT | Anakinra n/N (%) | Placebo n/N (%) | NNT |
| Anakinra vs placebo | |||||||||
| Bresnihan 199833 | 88/230 (38) | 32/119 (27) | 9.1 | No data | No data | No data | No data | No data | No data |
| Fleischman 200334 | No data | No data | No data | No data | No data | No data | No data | No data | No data |
| Anakinra + Methotrexate vs Placebo + Methotrexate | |||||||||
| Cohen 200235 | 41/105 (39) | 11/48 (23) | 6.3 | 22/105 (21) | 2/48 (4) | 5.9 | 9/105 (9) | 0/48 (0) | 11.1 |
| Cohen 200436 | 95/250 (38) | 55/251 (22) | 6.3 | 43/250 (17) | 20/251 (8) | 11.1 | 15/250 (6) | 5/251 (2) | 25 |
| Totals (w/o Genovese) | 224/585 (38) | 98/418 (23) | 6.7 | 65/355 (18) | 22/299 (7) | 9.1 | 24/355 (7) | 5/299 (2) | 20 |
| Anakinra + Methotrexate + Etanercept vs Placebo + Methotrexate + Etanercept | |||||||||
| Genovese 200437 | 50/81 (62) | 54/80 (68) | NA | 25/81 (31) | 33/80 (41) | NA | 11/81 (14) | 17/80 (21) | NA |
| Totals (w/Genovese) | 274/666 (41) | 152/498 (31) | 10 | 90/436 (21) | 55/379 (15) | 16.7 | 35/436 (8) | 22/379 (6) | 50 |
NA: not available.