Regression analyses for risk of RA due to shared epitope and DRB1*0901 according to age at onset.
| Population Tested | Explanatory Variables | OR (95% CI) | p |
|---|---|---|---|
| Probands with onset at < 16 yrs (n = 37) vs controls (n = 176) | *0901 | Eliminated | |
| Any SE | Eliminated | ||
| SE/0901 | 11.16 (2.65, 47.00) | 0.001 | |
| Constant | 0.179 | < 0.0001 | |
| Probands with onset at ≥ 16 yrs (n = 160) vs controls (n = 176) | *0901 | 2.50 (1.06, 5.89) | 0.037 |
| Any SE | 4.02 (2.22, 7.27) | < 0.0001 | |
| SE/*0901 | Eliminated | ||
| Constant | 0.276 | < 0.0001 |
The Cox and Snell R square values for the regressions were 0.052 for onset age < 16 years, and 0.074 for onset ≥ 16 years, respectively. RA probands and controls were entered in the regression.