Table 2.

Shared epitope and DRB1*0901 in RA probands and controls.

HLA-DRB1 GenotypeControls (n = 176) NAll RA (n = 250) NOR (95% CI) Controls vs RACCP+RA (n = 101) NOR (95% CI) Controls vs CCP+RACCP–RA (n = 22) NOR (95% CI) Controls vs CCP–RA
Any SE1162102.72 (1.72, 4.30) p < 0.0001842.56 (1.39, 4.69) p = 0.002171.76 (0.62, 5.00) p = NS
SE/X711242.62 (1.60, 4.30) p < 0.0001452.24 (1.16, 4.31) p = 0.015132.20 (0.74, 6.52) p = NS
SE/SE45862.87 (1.67, 4.91) p < 0.0001393.06 (1.54, 6.09) p = 0.00141.07 (0.27, 4.20) p = NS
Any *090112332.08 (1.04, 4.15) p = 0.035152.38 (1.07, 5.32) p = 0.03021.37 (0.29, 6.55) p = NS
SE/*09013184.47 (1.30, 15.43) p = 0.01074.29 (1.09, 17.0) p = 0.02500.98 (0.96, 1.0) p = NS
  • CCP: cyclic citrullinated peptide; N = number with genotype; SE: shared epitope. Any SE: genotypes with SE in combination with any DRB1 allele including SE. Any *0901: genotypes with *0901 in combination with any DRB1 allele. SE/X: genotypes with SE in combination with non-SE DRB1 allele. SE/*0901: genotypes with SE in combination with *0901. Odds ratios for RA were calculated for any SE, SE/X, and SE/SE genotypes versus genotypes without SE, or any *0901 genotypes versus genotypes without *0901, and for SE/*0901 genotypes versus any other genotypes.