Studies of health-related quality of life (HRQOL) in patients with gout.
| Author | Location | Study Population | Mean Age, yrs | HRQOL Measures | Results |
|---|---|---|---|---|---|
| Picavet30 | Netherlands | Self-reported gout (n = 138) | Not given | SF-36, EQ-5D | Gout patients had lower scores on all SF-36 (75.6 vs 87.8 for PF, 68.1 vs 85.8 for RP, 70.2 vs 84.1 for bodily pain, 64.7 vs 72.8 for GH, 60.8 vs 69.3 for vitality, and 73.2 vs 79.7 for MH), versus those without MSK disease. Similar results were noted for all EQ-5D dimensions |
| Alvarez-Nemegyei25 | Mexico | Gout* with chronic renal failure (n = 90) | 54 | HAQ | 47% of patients had MSK disability with average HAQ score 0.17 |
| Colwell27 | USA | Subjects in phase II trial of febuxostat (uric acid < 8.0 mg/dl; n = 126) | 54 | GAQ, SF-36 | Assessment of reliability, validity, and responsiveness of GAQ 2.0 vs SF-36. Patient SF-36 data not presented |
| Alvarez-Hernandez24 | Mexico | Gout* (n = 206) | 56 | HAQ-DI, SF-36 | Mean HAQ-DI score was 0.59. Patient SF-36 score data not presented |
| Hirsch28 | USA | Gout* (n = 308) | 62 | GAQ2.0, SF-36 | Assessment of reliability, validity, and responsiveness of GAQ 2.0 vs SF-36. Patient SF-36 data not presented |
| Khanna29 | USA | Chronic stable gout* (n = 80) | 60 | SF-36, HAQ-DI | Mean SF-36 PCS and MCS score was 38.9 and 48.6 (1.1 SD below and 0.1 SD below US general population mean)†. Mean HAQ-DI score was 0.6 |
| Roddy31 | UK | Gout* (n = 137) | 64 | WHO, QOL, BREF | Overall QOL, satisfaction with health, and physical health-related QOL were impaired in gout patients |
| Singh32 | USA | ICD-9 code for gout in Veterans Affairs healthcare system (n = 1581) | 68 | SF-36V | Mean SF-36 PCS and MCS score was 34.4 and 46.8 |
| Becker26 | USA | Treatment-failure gout (n = 110) | 59 | SF-36, HAQ-DI | Mean scores for SF-36 PF, RP, and PCS were 46.8, 35.0, and 34.2. Subjects with CVD had significantly lower PF than those without CVD (32.7 vs 48.6; p < 0.03). Mean HAQ-DI score at baseline was 1.0 |
↵† Summary scores were normed to the US general population with mean of 50 and SD of 10;
↵* defined by American Rheumatism Association classification. PF: physical functioning, RP: role physical, PCS: physical component summary, MCS: mental component summary, GH: general health; MH: mental health, EQ-5D: EuroQOL questionnaire, HAQ-DI: Health Assessment Questionnaire-Disability survey; WHO-QOL BREF: World Health Organization’s BREF Quality of Life assessment; SF-36V: a modified, validated version of SF-36 for veterans, MSK: musculoskeletal, CVD: cardiovascular disease.