Demographic, clinical, and quality of life characteristics at study entry and throughout observation interval.
| Variables | At Study Entry | Average During Observation Interval |
|---|---|---|
| Demographic | ||
| Age, yrs, mean (SD) | 40.6 (14.5) | |
| Male, % | 8.3 | |
| Caucasian, % | 71.5 | |
| Married, % | 48.4 | |
| Education, yrs, mean (SD) | 13.0 (3.1) | |
| Disease duration, yrs, mean (SD) | 8.1 (8.8) | |
| Clinical | ||
| Renal activity, % | 10.4 | 51* |
| Renal SLEDAI, mean (SD) | 1.8 (3.4) | 1.4 (2.2) |
| Median (IQR) | 0 (0, 4) | 0 (0, 4) |
| Nonrenal SLEDAI, mean (SD) | 4.9 (4.6) | 3.9 (2.9) |
| Median (IQR) | 4 (2, 7) | 3 (0, 6) |
| Total SLEDAI, mean (SD) | 6.7 (6.7) | 5.3 (4.1) |
| Median (IQR) | 4 (2, 9) | 4 (2, 8) |
| Renal SLICC/ACR-DI, mean (SD) | 0.1 (0.4) | 0.2 (0.5) |
| Median (IQR) | 0 (0, 0) | 0 (0, 0) |
| Nonrenal SLICC/ACR-DI, mean (SD) | 1.0 (1.5) | 1.4 (1.7) |
| Median (IQR) | 0 (0, 2) | 1 (0, 2) |
| Total SLICC/ACR-DI, mean (SD) | 1.1 (1.6) | 1.5 (1.9) |
| Median (IQR) | 1 (0, 2) | 1 (0, 3) |
| Slope of change in renal SLEDAI (95% CI) | NA | −0.06 (−0.07, −0.05) |
| SF-36 | ||
| Physical function, mean (SD) | 67.4 (26.3) | 70.6 (23.7) |
| Role-physical, mean (SD) | 44.2 (43.2) | 52.4 (35.8) |
| Bodily pain, mean (SD) | 58.3 (26.8) | 61.7 (22.1) |
| Vitality, mean (SD) | 47.2 (22.5) | 49.6 (19.2) |
| Role-emotional, mean (SD) | 63.8 (42.6) | 67.0 (33.4) |
| Mental health, mean (SD) | 65.3 (20.6) | 67.5 (33.4) |
| Social function, mean (SD) | 66.5 (27.4) | 70.4 (21.4) |
| General health, mean (SD) | 51.4 (23.1) | 52.5 (21.0) |
| Physical component summary, mean (SD) | 40.2 (11.6) | 41.8 (10.3) |
| Mental component summary, mean (SD) | 45.3 (20.6) | 46.4 (9.7) |
| Slope of change in physical component summary (95% CI) | NA | 0.36 (0.32, 0.40) |
| Slope of change in mental component summary (95% CI) | NA | 0.36 (0.32, 0.40) |
SLEDAI: Systemic Lupus Erythematosus Disease Activity Index; SLICC/ACR-DI: Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index; NA: not applicable.
↵* Refers to percentage of patients with at least one non-zero renal activity score over the course of study.