Patterns of dose/frequency change 2003–2005.
| Initial Drug | N | Frequency (Interval)/Dose Change, mg dose | N (%) | Median Days to First (interval)/Dose Change (75th–25th %) | Frequency (interval)/Dose Escalation |
|---|---|---|---|---|---|
| Etanercept | 2404 | Constant dose | 1500 (62.40) | No | |
| 25 twice weekly→50 once weekly | 823 (34.23) | 464 (644–314) | No | ||
| 50 once weekly→25 twice weekly | 81 (3.37) | 167 (307–69) | No | ||
| Adalimumab | 963 | Constant dose | 698 (72.48) | No | |
| Frequency increase (every other wk→once weekly) | 171 (17.76) | 162 (290–84) | Yes | ||
| Frequency decrease (once weekly→ every other wk) | 94 (9.76) | 107 (197–56) | No | ||
| Infliximab | 1253 | Constant dose, interval decrease | 177 (14.13) | 158 (207–133) | Yes |
| Dose increase, interval decrease | 71 (5.67) | 152 (196–139) | Yes | ||
| Dose increase, constant interval | 232 (18.52) | 155 (202–146) | Yes | ||
| Constant dose, constant interval | 334 (26.66) | No | |||
| Constant dose, interval increase | 217 (17.32) | 180 (252–133) | No | ||
| Dose decrease, constant interval | 62 (4.95) | 153.5 (165–126) | No | ||
| Dose decrease, interval increase | 26 (2.08) | 161.5 (225–126) | No | ||
| Dose decrease, interval decrease | 44 (3.51) | 176.5 (251.5–140) | Yes/No | ||
| Dose increase, interval increase | 90 (7.18) | 140 (175–117) | Yes/No |