Table 5.

Secondary analyses estimating hazard ratio (HR) of organ damage by cumulative prednisone dose.

	Unadjusted Model		Conventionally-adjusted Model		Weighted Model
	HR	95% CI	HR	95% CI	HR	95% CI
Cumulative average prednisone dose (outcome death or organ damage) (mg/mo)
0 dose	Ref		Ref		Ref
> 0–180	1.44	0.92, 2.24	1.78	1.00, 3.18	1.06	0.50, 2.26
> 180–360	2.13	1.29, 3.51	2.39	1.17, 4.87	1.53	0.60, 3.90
> 360–540	2.93	1.64, 5.21	3.33	1.49, 7.47	1.58	0.56, 4.45
> 540	4.22	2.43, 7.32	4.08	1.78, 9.34	2.63	0.94, 7.36
Average 3-month prednisone dose (censoring at pulse methylprednisolone therapy)^† m (g/mo)
0 dose	Ref		Ref		Ref
> 0–180	1.73	1.01, 2.95	1.45	0.81, 2.59	1.14	0.57, 2.28
> 180–360	2.28	1.22, 4.25	1.83	0.95, 3.50	1.67	0.73, 3.85
> 360–540	1.57	0.64, 3.86	1.24	0.49, 3.16	0.91	0.31, 2.67
> 540	3.02	1.44, 6.33	2.61	1.19, 5.72	2.20	0.89, 5.43
Cumulative average prednisone dose (controlling for pulse methylprednisolone therapy)^* (mg/mo)
0 dose	Ref		Ref		Ref
> 0–180	1.44	0.93, 2.24	1.78	1.01, 3.16	1.01	0.47, 2.15
> 180–360	1.93	1.16, 3.22	2.24	1.09, 4.59	1.21	0.46, 3.15
> 360–540	2.87	1.61, 5.11	3.49	1.56, 7.78	1.51	0.54, 4.21
> 540	4.24	2.44, 7.35	4.36	1.90, 9.99	2.49	0.85, 7.30