Table 2.

Hazard ratios (HR) for stopping tumor-necrosis factor blockade for patients achieving defined response or disease states according to various criteria. Total n = 1789.

6 Weeks3 Months
HR (95% CI)pValid nHR (95% CI)pValid n
Response criteria
  ACR
    ACR200.55 (0.43–0.71)< 0.0015260.56 (0.47–0.66)< 0.0011208
    ACR500.64 (0.48–0.85)0.0025260.55 (0.46–0.66)< 0.0011208
    ACR701.06 (0.59–1.90)0.8505260.56 (0.42–0.75)< 0.0011208
  EULAR original
    Overall0.59 (0.44–0.77)< 0.0014930.47 (0.39–0.56)< 0.0011151
    Moderate0.95 (0.66–1.34)0.7634930.87 (0.73–1.04)0.1231151
    Good0.72 (0.53–0.97)0.0324930.58 (0.47–0.71)< 0.0011151
  EULAR modified
    Overall0.63 (0.48–0.83)0.0014930.48 (0.40–0.57)< 0.0011151
    Moderate1.03 (0.69–1.53)0.8954930.96 (0.77–1.19)0.6951151
    Good0.61 (0.49–0.79)< 0.0014930.56 (0.47–0.67)< 0.0011151
  SDAI
    Overall0.62 (0.45–0.81)0.0015120.47 (0.39–0.57)< 0.0011179
    Minor0.80 (0.56–1.15)0.2295121.06 (0.87–1.28)0.5571179
    Major0.65 (0.50–0.86)0.0025120.58 (0.48–0.69)< 0.0011179
  CDAI
    Overall0.75 (0.57–0.99)0.0445170.53 (0.44–0.65)< 0.0011181
    Minor0.94 (0.64–1.37)0.7425171.20 (0.99–1.47)0.0671181
    Major0.69 (0.54–0.90)0.0055170.57 (0.48–0.68)< 0.0011181
Disease states
  EULAR original
    Remission1.03 (0.65–1.62)0.9115020.65 (0.51–0.82)< 0.0011173
    Low0.69 (0.52–0.93)0.0155020.60 (0.49–0.72)< 0.0011173
    Moderate1.04 (0.81–1.34)0.7695020.98 (0.83–1.16)0.8031173
    High1.60 (1.15–2.23)0.0055022.18 (1.78–2.69)< 0.0011173
  EULAR modified
    Remission1.33 (0.82–2.16)0.2425020.65 (0.50–0.85)0.0011173
    Low0.60 (0.45–0.79)< 0.0015020.61 (0.50–0.73)< 0.0011173
    Moderate1.24 (0.96–1.60)0.1085021.08 (0.91–1.29)0.3861173
    High1.86 (1.28–2.69)0.0015022.15 (1.72–2.69)< 0.0011173
  SDAI
    Remission1.85 (0.86–4.02)0.1185120.60 (0.41–0.87)0.0061182
    Low0.81 (0.62–1.06)0.1255120.67 (0.56–0.81)< 0.0011182
    Moderate0.90 (0.70–1.15)0.3895120.90 (0.76–1.07)0.2241182
    High1.73 (1.26–2.39)0.0015122.19 (1.79–2.68)< 0.0011182
  CDAI
    Remission1.82 (0.84–3.945)0.1295170.64 (0.441–0.918)0.0161189
    Low0.84 (0.64–1.10)0.1925170.70 (0.58–0.84)< 0.0011189
    Moderate0.87 (0.68–1.12)0.2375170.84 (0.70–1.00)0.0481189
    High1.62 (1.20–2.19)0.0025172.24 (1.84–2.73)< 0.0011189