Associations between the baseline biomarker level and change in van der Heijde-modified Sharp score from baseline to 5 and 10 years (dependent variable), results from univariate linear and logistic regression analyses.
| Univariate Linear Regression | Univariate Logistic Regression | |||||||
|---|---|---|---|---|---|---|---|---|
| 5 Years | 10 Years | 5 Years | 10 Years | |||||
| B (95% CI) | p | B (95% CI) | p | OR (95% CI) | p | OR (95% CI) | p | |
| OPG | –0.49 (–1.59 to 0.62) | 0.37 | –0.50 (–1.52 to 1.41) | 0.94 | 0.99 (0.88 to 1.12) | 0.87 | 1.06 (0.92 to 1.21) | 0.42 |
| RANKL | 1.1 (–2.2 to 4.3) | 0.65 | 0.51 (–3.85 to 4.88) | 0.81 | 1.48 (0.61 to 3.57) | 0.38 | 1.51 (0.65 to 3.49) | 0.41 |
| RANKL/OPG | 2.4 (–22.5 to 27.3) | 0.80 | 2.3 (–18.5 to 19.4) | 0.84 | 1.43 (0.54 to 149.1) | 0.09 | 1.43 (0.12 to 99.3) | 0.46 |
| COMP | 0.33 (–0.82 to 1.50) | 0.73 | 0.54 (–1.30 to 2.38) | 0.56 | 1.08 (0.95 to 1.24) | 0.23 | 0.94 (0.82 to 1.07) | 0.36 |
| YKL-40 | 0.02 (–0.04 to 0.07) | 0.68 | 0.01 (–0.01 to 0.10) | 0.77 | 1.00 (0.99 to 1.01) | 0.51 | 1.00 (0.99 to 1.01) | 0.16 |
| CTX-I | 5.4 (–1.9 to 12.6) | 0.14 | 20.2 (7.4 to 33.0) | 0.05 | 1.97 (0.72 to 5.36) | 0.19 | 2.76 (0.83 to 9.14) 0.10 | |
| C2C | –0.09 (–0.35 to 0.17) | 0.31 | –0.16 (–0.58 to 0.26) | 0.46 | 0.99 (0.96 to 1.02) | 0.47 | 0.99 (0.97 to 1.02) | 0.67 |
| CRP | 0.51 (0.26 to 0.75) | < 0.01 | 0.73 (0.30 to 1.15) | < 0.01 | 1.06 (1.01 to 1.10) | 0.01 | 1.09 (1.03 to 1.12) | < 0.01 |
| ESR | 0.29 (0.15 to 0.43) | < 0.01 | 0.12 (0.08 to 0.57) | < 0.01 | 1.03 (1.01 to 1.05) | < 0.01 | 1.05 (1.02 to 1.08) | < 0.01 |