IGF-1 | IGFBP-3 | IGFBP-3/IGF-1 Ratio | ||||
---|---|---|---|---|---|---|
Referent: Highest Tertile | Referent: Highest Tertile | Referent: Lowest Tertile | ||||
Middle | Lowest | Middle | Lowest | Middle | Highest | |
Model 1: stratified by BMI | ||||||
No Pain, obese | 0.98 (0.64, 1.51) | 1.46 (0.89, 2.39) | 0.69 (0.57, 0.84) | 0.76 (0.56, 1.03) | 1.54 (1.00, 2.38)** | 2.01 (1.27, 3.20)** |
CWP, not obese | 1.30 (0.92, 1.85) | 1.27 (0.82, 1.96) | 1.34 (0.90, 2.01) | 1.38 (0.88, 2.17) | 1.25 (0.97, 1.61) | 0.97 (0.61, 1.54) |
CWP, obese | 1.57 (0.98, 2.52) | 1.98 (1.03, 3.81)** | 0.69 (0.32, 1.49) | 1.06 (0.77, 1.46) | 1.44 (0.67, 3.07) | 2.50 (1.33, 4.71)** |
Model 2: stratified by no. of comorbidities | ||||||
No pain, ≥ 1 symptoms | 1.30 (0.97, 1.76) | 2.07 (1.64, 2.61)** | 1.40 (1.06, 1.86)** | 2.26 (1.65, 3.09)** | 1.08 (0.72, 1.63) | 1.26 (0.91, 1.74) |
CWP, 0 symptoms | 1.22 (0.76, 1.98) | 0.98 (0.46, 2.08) | 1.41 (0.84, 2.36) | 1.03 (0.43, 2.45) | 1.06 (0.62, 1.84) | 1.06 (0.57, 1.98) |
CWP, ≥ 1 symptoms | 1.92 (1.35, 2.72)** | 2.85 (1.81, 4.51)** | 1.28 (0.79, 2.10) | 2.58 (2.01, 3.31) | 1.47 (0.89, 2.42) | 1.55 (0.88, 2.73) |
Model 3: Stratified by PPT time to walk 50 feet | ||||||
No pain, slow PPT time | 1.37 (0.85, 2.20) | 1.91 (1.10, 3.31)** | 1.46 (0.98, 2.17) | 2.20 (1.32, 3.65)** | 0.86 (0.64, 1.15) | 0.97 (0.69, 1.38) |
CWP, fast PPT time | 1.40 (0.87, 2.26) | 1.20 (0.90, 1.59) | 1.04 (0.76, 1.42) | 1.19 (0.88, 1.60) | 1.12 (0.87, 1.45) | 1.03 (0.73, 1.46) |
CWP, slow PPT time | 1.49 (0.85, 2.63) | 2.69 (1.17, 6.21)** | 1.94 (0.95, 3.99) | 3.02 (1.73, 5.27)** | 1.46 (0.91, 2.34) | 1.69 (0.77, 3.70) |
Model 4: Stratified by BDI | ||||||
No pain, depressive symptoms | 1.15 (0.74, 1.79) | 1.41 (0.85, 2.32) | 1.41 (0.85, 2.33) | 1.63 (0.94, 2.83) | 0.92 (0.56, 1.52) | 0.98 (0.64, 1.48) |
CWP, no depressive symptoms | 1.51 (0.97, 2.35) | 1.41 (0.93, 2.13) | 1.13 (0.68, 1.90) | 1.17 (0.92, 1.48) | 1.10 (0.79, 1.52) | 1.36 (0.80, 2.31) |
CWP, depressive symptoms | 1.13 (0.78, 1.63) | 1.46 (0.82, 2.60) | 1.43 (0.90, 2.27) | 1.94 (1.33, 2.84)** | 1.36 (0.93, 1.99) | 0.91 (0.56, 1.48) |
↵* Fast PPT walk time defined as ≤ 15.2 s (80% centile), slow if ≥ 15.3 s.
↵† No depressive symptoms: classified as normal; depressive symptoms: classified as mild to extreme. Depressive symptoms corresponds to 20% of the entire sample. Robust standard errors were used to account for center.
↵** p < 0.05.